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Surgery
Volume 131, Issue 6
, Pages 595-600
, June 2002
Ubiquitin proteasome inhibition and cancer therapy
References
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- . The ubiquitin-proteasome proteolytic pathway. Cell. 1994;79:13–21
- Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994;78:761–777
- . Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science. 1995;268:726–731
- . The proteasome inhibitor PS-341 in cancer therapy. Clin Cancer Res. 1999;5:2638–2645
- Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett. 1998;8:333–338
- Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999;59:2615–2622
- 26S proteasome inhibition induces apoptosis and limits growth in human pancreatic cancer. J Cell Biochem. 2001;82:110–122
- Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995;267:1022–1024
- . In vivo ubiquination and proteasome-mediated degradation of p53. Cancer Res. 1996;56:2649–2654
- Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med. 1997;3:231–234
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p21WAF1 expression is associated with improved survival after adjuvant chemoradiation for pancreatic cancer.
Surgery. 2000;128:120–130
- . The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 1994;78:773–785
- . TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappa B. Science. 1996;274:784–787
- . Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappa B. Nat Med. 1999;5:412–417
- . NF-(B antiapoptosis: induction of TRAF1, TRAF2, c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998;281:1680–1683
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NF-kappa B activation by campothecin.
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PS-341 is active in multiple myeloma: preliminary report of a phase I trial of the proteasome inhibitor PS-341 in patients with hematologic malignancies.
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Phase I trial of the proteasome inhibitor PS-341 in advanced malignancy.
ASCO Proceedings. 2000;19:189a
☆ Reprint requests: Mark P. Callery, MD, FACS, Division of General Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215.
PII: S0039-6060(02)00002-8
doi: 10.1067/msy.2002.121890
© 2002 Mosby, Inc. All rights reserved.
« Previous
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Surgery
Volume 131, Issue 6
, Pages 595-600
, June 2002
