Surgery
Volume 143, Issue 6 , Pages 723-731 , June 2008

Intra-abdominal vagal blocking (VBLOC therapy): Clinical results with a new implantable medical device

  • M. Camilleri, MD

      Affiliations

    • The Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationReprint requests: Michael Camilleri, MD, Mayo Clinic, Charlton 8-110, 200 First St. S.W., Rochester, MN 55905.
    • Both M. Camilleri and J. Toouli are co-lead authors.
    • ,
  • J. Toouli, MD, PhD

      Affiliations

    • Flinders University, Adelaide, South Australia
    • Both M. Camilleri and J. Toouli are co-lead authors.
    • ,
  • M.F. Herrera, MD

      Affiliations

    • Instituto Nacional de la Nutrition, Mexico City, Mexico
    • ,
  • B. Kulseng, MD, PhD

      Affiliations

    • St. Olav's University Hospital, Trondheim, Norway
    • ,
  • L. Kow, MD, PhD

      Affiliations

    • Flinders University, Adelaide, South Australia
    • ,
  • J.P. Pantoja, MD

      Affiliations

    • Instituto Nacional de la Nutrition, Mexico City, Mexico
    • ,
  • R. Marvik, MD, PhD

      Affiliations

    • St. Olav's University Hospital, Trondheim, Norway
    • ,
  • G. Johnsen, MD

      Affiliations

    • St. Olav's University Hospital, Trondheim, Norway
    • ,
  • C.J. Billington, MD

      Affiliations

    • University of Minnesota, Minneapolis, Minnesota
    • ,
  • F.G. Moody, MD

      Affiliations

    • University of Texas Medical School at Houston, Houston, Texas
    • ,
  • M.B. Knudson, PhD

      Affiliations

    • EnteroMedics Inc, St. Paul, Minnesota
    • ,
  • K.S. Tweden, PhD

      Affiliations

    • EnteroMedics Inc, St. Paul, Minnesota
    • ,
  • M. Vollmer, BA

      Affiliations

    • EnteroMedics Inc, St. Paul, Minnesota
    • ,
  • R.R. Wilson, MD

      Affiliations

    • Health Research LLC, Arden Hills, Minnesota
    • ,
  • M. Anvari, MD, PhD

      Affiliations

    • McMaster University, Hamilton, Ontario, Canada

,Accepted 14 March 2008.

References 

  1. Kronborg O. Truncal vagotomy and drainage in 500 patients with duodenal ulcer. Scand J Gastroenterol. 1971;6:501–509
  2. Goligher JC, Pulvertaft CN, Irvin TT, Johnston D, Walker B, Hall RA, et al. Five- to eight-year results of truncal vagotomy and pyloroplasty for duodenal ulcer. Br Med J. 1972;1:7–13
  3. Kral JG. Vagotomy for treatment of severe obesity. Lancet. 1978;1:307–308
  4. Smith DK, Sarfeh J, Howard L. Truncal vagotomy in hypothalamic obesity. Lancet. 1983;1:1330–1331
  5. Groetz L, Kral JB. A five- to eight-year follow-up study of truncal vagotomy as a treatment for morbid obesity. Proceedings, Third Annual Meeting, American Society for Bariatric Surgery, Iowa City, Iowa, 18–20 June, 1986, p. 145.
  6. Takahashi T, Owyang C. Characterization of vagal pathways mediating gastric accommodation reflex in rats. J Physiol. 1997;504:479–488
  7. Tweden KS, Sarr MG, Camilleri M, Kendrick ML, Moody FG, Bierk MD, et al. Vagal blocking for obesity control (VBLOC): studies of pancreatic and gastric function and safety in a porcine model. Surg Obes Relat Disord. 2006;2:301
  8. Tweden KS, Anvari M, Bierk MD, Billington CJ, Camilleri M, Honda CN, et al. Vagal blocking for obesity control (VBLOC): concordance of effects of very high frequency blocking current at the neural and organ levels using two preclinical models. Gastroenterology. 2006;130:A-148
  9. Dixon JB, McPhail T, O'Brien PE. Minimal reporting requirements for weight loss: current methods not ideal. Obes Surg. 2005;15:1034–1039
  10. Stubbs RJ, Hughes DA, Johnstone AM, Rowley E, Reid C, Elia M, et al. The use of visual analogue scales to assess motivation to eat in human subjects: a review of their reliability and validity with an evaluation of new hand-held computerized systems for temporal tracking of appetite ratings. Br J Nutr. 2000;84:405–415
  11. Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obesity. 2000;24:38–48
  12. Taylor IL, Feldman M. Effect of cephalic-vagal stimulation on insulin, gastric inhibitory polypeptide, and pancreatic polypeptide release in humans. J Clin Endocrinol Metab. 1982;55:1114–1117
  13. Greydanus MP, Vassallo M, Camilleri M, Nelson DK, Hanson RB, Thomforde GM. Neurohormonal factors in functional dyspepsia: Insights on pathophysiological mechanisms. Gastroenterology. 1991;100:1311–1318
  14. Balaji NS, Crookes PF, Banki F, Hagen JA, Ardill JE, DeMeester TR. A safe and noninvasive test for vagal integrity revisited. Arch Surg. 2002;137:954–959
  15. Williams DL, Grill HJ, Cummings DE, Kaplan JM. Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology. 2003;144:5184–5187
  16. Kral JG, Gortz L, Hermansson G, Wallin GS. Gastroplasty for obesity: long-term weight loss improved by vagotomy. World J Surg. 1993;17:75–79

 M.C. receives consulting fees as part of a business alliance between Mayo Clinic and EnteroMedics, Inc. M.A., C.J.B., F.G.M., and R.R.W. are consultants of EnteroMedics Inc. K.S.T., M.V., and M.B.K. are employees of EnteroMedics Inc. This work was completely funded by EnteroMedics Inc.

PII: S0039-6060(08)00182-7

doi: 10.1016/j.surg.2008.03.015

Surgery
Volume 143, Issue 6 , Pages 723-731 , June 2008

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