Surgery
Volume 144, Issue 4 , Pages 591-597 , October 2008

Theraputic anticoagulation in the trauma patient: Is it safe?

,Accepted 19 June 2008.

References 

  1. Knudson MM, Ikossi DG. Venous thromboembolism after trauma. Curr Opinion Crit Care. 2004;10:539–548
  2. Knudson MM, Ikossi DG, Khaw L, Morabito D, Speetzen LS. Thromboembolism after trauma: an analysis of 1602 episodes from the American College of Surgeons National Trauma Data Bank. Ann Surg. 2004;240:490–496discussion 6-8
  3. Schultz DJ, Brasel KJ, Washington L, Goodman LR, Quickel RR, Lipchik RJ, et al. Incidence of asymptomatic pulmonary embolism in moderately to severely injured trauma patients. J Trauma-Injury Infect Crit Care. 2004;56:727–731discussion 31-3
  4. Bates SM, Ginsberg JS. Clinical practice. Treatment of deep-vein thrombosis. [see comment] N Engl J Med. 2004;351:268–277
  5. Ginsberg JS. Management of venous thromboembolism [see comment]. N Engl J Med. 1996;335:1816–1828
  6. Blajchman MA, Young E, Ofosu FA. Effects of unfractionated heparin, dermatan sulfate and low molecular weight heparin on vessel wall permeability in rabbits. Ann NY Acad Sci. 1989;556:245–254
  7. Fernandez F, N'Guyen P, Van Ryn J, Ofosu FA, Hirsh J, Buchanan MR. Hemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect. Thrombosis Research. 1986;43:491–495
  8. Levine MN, Raskob G, Beyth RJ, Kearon C, Schulman S. Hemorrhagic complications of anticoagulant treatment: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(Suppl 3):287S–310S
  9. Gubitz G, Counsell C, Sandercock PAG. Anticoagulation for acure ischaemic stroke (Cochran Review). The Cochran Library. 2002;
  10. Klein W, Buchwald A, Hillis SE, Monrad S, Sanz G, Turpie AG, et al. Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC) [see comment] [erratum appears in Circulation 1998 Feb 3;97:413]. Circulation. 1997;96:61–68
  11. Brathwaite CE, Mure AJ, O'Malley KF, Spence RK, Ross SE. Complications of anticoagulation for pulmonary embolism in low risk trauma patients. Chest. 1993;104:718–720
  12. Anand SS, Yusuf S, Pogue J, Ginsberg JS, Hirsh J. Organization to Assess Strategies for Ischemic Syndromes I. Relationship of activated partial thromboplastin time to coronary events and bleeding in patients with acute coronary syndromes who receive heparin. Circulation. 2003;107:2884–2888
  13. Campbell NR, Hull RD, Brant R, Hogan DB, Pineo GF, Raskob GE. Aging and heparin-related bleeding. Arch Int Med. 1996;156:857–860
  14. Glazier R, Cornwell E. Randomized prospective trial of continuous vs inermittent heparin therapy. JAMA. 1976;236:1365–1367

 This work and J. A. Claridge were supported in part by Grant Number 1KL2RR024990 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH), and NIH Roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.

 Presented at the 65th Annual Meeting of the Central Surgical Association, Cincinnati, Ohio, March 6–8, 2008.

PII: S0039-6060(08)00424-8

doi: 10.1016/j.surg.2008.06.022

Surgery
Volume 144, Issue 4 , Pages 591-597 , October 2008

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