Surgery
Volume 145, Issue 5 , Pages 508-513, May 2009

Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer

  • Jen-Chih Lin, MD

      Affiliations

    • Department of Otolaryngology, Kaohsiung Municipal Hsaio-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Wen-Rei Kuo, MD

      Affiliations

    • Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Feng-Yu Chiang, MD

      Affiliations

    • Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Pi-Jung Hsiao, MD

      Affiliations

    • Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Ka-Wo Lee, MD

      Affiliations

    • Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Che-Wei Wu, MD

      Affiliations

    • Department of Otolaryngology, Kaohsiung Municipal Hsaio-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Suh-Hang Hank Juo, MD, PhD

      Affiliations

    • Graduate Institute of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationReprint requests: Suh-Hang Hank Juo, MD, PhD, No. 100 Tzyou First Road, Kaohsiung City 807, Taiwan.

Accepted 15 December 2008. published online 23 February 2009.

Background

The antioxidant enzyme glutathione peroxidase 3 (GPX3) can lessen the oxidative stress in the thyroid gland. We tested for the association between tagging single nucleotide polymorphisms (tSNPs) of the GPX3 gene and the risk of differentiated thyroid cancer (DTC).

Methods

A total of 6 tSNPs (rs3763013, rs8177412, rs3805435, rs3828599, rs3792796, and rs2070593) of GPX3 were genotyped in Chinese DTC cases (n = 268) and controls (n = 378). Multivariate logistic regression was performed to estimate the genetic effect with adjustment for age and sex.

Results

There was no significant finding of genotype analysis in each tSNP associated with DTC, papillary thyroid carcinoma, or patients with regional lymph node metastasis. In the older group (age ≥45 years), subjects who carried at least 1 G allele of rs3805435 had a decreased risk of DTC compared with patients of AA homozygote (sex- and age-adjusted odds ratio [OR] = 0.50, P = .009). An individual with at least 1 T allele of rs3828599 had a decreased risk of DTC compared with an individual of the CC homozygote (sex- and age-adjusted OR = 0.53, P = .018). An individual carrying the TC genotype of rs8177412 in the older group had an increased risk of DTC than controls (sex- and age-adjusted OR = 1.73, P = .037).

Conclusion

We found that the G allele of rs3805435 or the T allele of rs3828599 may exert a protective effect for DTC in the older population, whereas the C allele of rs8177412 confers an increased risk effect for DTC.

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 J.-C.L. and W.-R.K. contributed equally to this work.

 Supported by Intramural Grants QC-094006 and 94-KMUH007 from the Kaohsiung Medical University Hospital; Grant KMU-EM-2.3.a from the Education of Ministry, Taiwan; and Grant 94-2314B037-104 from the National Science Council, Taiwan NSC.

PII: S0039-6060(09)00010-5

doi:10.1016/j.surg.2008.12.008

Surgery
Volume 145, Issue 5 , Pages 508-513, May 2009

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