Surgery
Volume 145, Issue 5 , Pages 508-513 , May 2009

Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer

  • Jen-Chih Lin, MD

      Affiliations

    • Department of Otolaryngology, Kaohsiung Municipal Hsaio-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Wen-Rei Kuo, MD

      Affiliations

    • Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Feng-Yu Chiang, MD

      Affiliations

    • Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Pi-Jung Hsiao, MD

      Affiliations

    • Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Ka-Wo Lee, MD

      Affiliations

    • Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Che-Wei Wu, MD

      Affiliations

    • Department of Otolaryngology, Kaohsiung Municipal Hsaio-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Otolaryngology Head and Neck Surgery, Division of Endocrinology and Metabolism, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • ,
  • Suh-Hang Hank Juo, MD, PhD

      Affiliations

    • Graduate Institute of Medical Genetics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    • Corresponding Author InformationReprint requests: Suh-Hang Hank Juo, MD, PhD, No. 100 Tzyou First Road, Kaohsiung City 807, Taiwan.

,Accepted 15 December 2008.

References 

  1. Baverstock K, Egloff B, Pinchera A, Ruchti C, Williams D. Thyroid cancer after Chernobyl. Nature. 1992;359:21–22
  2. Cardis E, Kesminiene A, Ivanov V, Malakhova I, Shibata Y, Khrouch V, et al. Risk of thyroid cancer after exposure to 131I in childhood. J Natl Cancer Inst. 2005;97:724–732
  3. Little JB. Radiation carcinogenesis. Carcinogenesis. 2000;21:397–404
  4. Emerit I. Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radic Biol Med. 1994;16:99–109
  5. Sadani GR, Nadkarni GD. Role of tissue antioxidant defense in thyroid cancers. Cancer Lett. 1996;109:231–235
  6. Maier J, van Steeg H, van Oostrom C, Karger S, Paschke R, Krohn K. Deoxyribonucleic acid damage and spontaneous mutagenesis in the thyroid gland of rats and mice. Endocrinology. 2006;147:3391–3397
  7. Howie AF, Arthur JR, Nicol F, Walker SW, Beech SG, Beckett GJ. Identification of a 57-kilodalton selenoprotein in human thyrocytes as thioredoxin reductase and evidence that its expression is regulated through the calcium-phosphoinositol signaling pathway. J Clin Endocrinol Metab. 1998;83:2052–2058
  8. Howie AF, Walker SW, Akesson B, Arthur JR, Beckett GJ. Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis. Biochem J. 1995;308:713–717
  9. Schmutzler C, Mentrup B, Schomburg L, Hoang-Vu C, Herzog V, Kohrle J. Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3. Biol Chem. 2007;388:1053–1059
  10. International HapMap Consortium. A haplotype map of the human genome. Nature. 2005;437:1299–1320
  11. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
  12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–575
  13. Tzeng JY, Wang CH, Kao JT, Hsiao CK. Regression-based association analysis with clustered haplotypes through use of genotypes. Am J Hum Genet. 2006;78:231–242
  14. Shaha AR. Controversies in the management of thyroid nodule. Laryngoscope. 2000;110:183–193
  15. Kohrle J. The deiodinase family: selenoenzymes regulating thyroid hormone availability and action. Cell Mol Life Sci. 2000;57:1853–1863
  16. Hasegawa Y, Takano T, Miyauchi A, Matsuzuka F, Yoshida H, Kuma K, et al. Decreased expression of glutathione peroxidase mRNA in thyroid anaplastic carcinoma. Cancer Lett. 2002;182:69–74
  17. Takano T, Hasegawa Y, Matsuzuka F, Miyauchi A, Yoshida H, Higashiyama T, et al. Gene expression profiles in thyroid carcinomas. Br J Cancer. 2000;83:1495–1502
  18. Menth M, Schmutzler C, Mentrup B, Hoang-Vu C, Takahashi K, Honjoh T, et al. Selenoprotein expression in Hürthle cell carcinomas and in the human Hürthle cell carcinoma line XTC.UC1. Thyroid. 2005;15:405–416

 J.-C.L. and W.-R.K. contributed equally to this work.

 Supported by Intramural Grants QC-094006 and 94-KMUH007 from the Kaohsiung Medical University Hospital; Grant KMU-EM-2.3.a from the Education of Ministry, Taiwan; and Grant 94-2314B037-104 from the National Science Council, Taiwan NSC.

PII: S0039-6060(09)00010-5

doi: 10.1016/j.surg.2008.12.008

Surgery
Volume 145, Issue 5 , Pages 508-513 , May 2009

Article Tools