Surgery
Volume 147, Issue 2 , Pages 185-194 , February 2010

Prevalence and clinical relevance of pathological hepatic changes occurring after neoadjuvant chemotherapy for colorectal liver metastases

  • Catherine Hubert, MD

      Affiliations

    • Division of Hepatobiliary and Pancreatic Surgery, Department of Abdominal Surgery and Transplantation, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Caroline Fervaille, MD

      Affiliations

    • Department of Pathology, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Christine Sempoux, MD, PhD

      Affiliations

    • Department of Pathology, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Yves Horsmans, MD, PHD

      Affiliations

    • Department of Gastroenterology, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Yves Humblet, MD, PhD

      Affiliations

    • Department of Oncology, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Jean-Pascal Machiels, MD, PhD

      Affiliations

    • Department of Oncology, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Francis Zech, MD

      Affiliations

    • Department of Internal Medicine, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Antonino Ceratti

      Affiliations

    • Department of Oncology, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • ,
  • Jean-François Gigot, MD, PhD, FRCS

      Affiliations

    • Division of Hepatobiliary and Pancreatic Surgery, Department of Abdominal Surgery and Transplantation, Saint-Luc University Hospital, Université Catholique de Louvain (UCL), Brussels, Belgium
    • Corresponding Author InformationReprint requests: Jean-François Gigot, MD, PhD, FRCS, Division of Hepato-Biliary and Pancreatic Surgery, Department of Abdominal Surgery and Transplantation, Saint-Luc University Hospital, Hippocrate Avenue 10, 1200 Brussels, Belgium.

,Accepted 8 January 2009.

References 

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  2. Adam R, Avisar E, Ariche A, Giachetti S, Azoulay D, Castaing D, et al. Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol. 2001;8:347–353
  3. Pozzo C, Basso M, Cassano A, Quirino M, Schinzari G, Trigila N, et al. Neoadjuvant treatment of unresectable liver disease with irinotecan and 5-fluorouracil plus folinic acid in colorectal cancer patients. Ann Oncol. 2004;15:933–939
  4. Folprecht G, Grothey A, Alberts S, Raab HR, Kohne CH. Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates. Ann Oncol. 2005;16:1311–1319
  5. Parikh AA, Gentner B, Wu TT, Curley SA, Ellis LM, Vauthey JN. Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy. J Gastrointest Surg. 2003;7:1082–1088
  6. Fernandez FG, Ritter J, Goodwin JW, Linehan DC, Hawkins WG, Strasberg SM. Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases. J Am Coll Surg. 2005;200:845–853
  7. Rubbia-Brandt L, Audard V, Sartoretti P, Roth AD, Brezault C, Le Charpentier M, et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Ann Oncol. 2004;15:460–466
  8. Hubert C, Sempoux C, Horsmans Y, Rahier J, Humblet Y, Gigot JF. Nodular regenerative hyperplasia: a deleterious consequence of long-standing chemotherapy for colorectal liver metastases?. Liver Int. 2007;
  9. Rubbia-Brandt L, Mentha G, Terris B. Sinusoidal obstruction syndrome is a major feature of hepatic lesions associated with oxaliplatin neoadjuvant chemotherapy for liver colorectal metastases. J Am Coll Surg. 2006;202:199–200
  10. Karoui M, Penna C, min-Hashem M, Mitry E, Benoist S, Franc B, et al. Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg. 2006;243:1–7
  11. Vauthey JN, Pawlik TM, Ribero D, Wu TT, Zorzi D, Hoff PM, et al. Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases. J Clin Oncol. 2006;24:2065–2072
  12. American Society of Anesthesiologists. New classification of physical status. Anesthesiology. 1963;24:111
  13. Strasberg SM. Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg. 2005;12:351–355
  14. Sempoux C, Horsmans Y, Geubel A, Fraikin J, Van Beers BE, Gigot JF, et al. Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event. Hepatology. 1997;26:128–134
  15. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467–2474
  16. Kleiner DE, Brunt EM, Van NM, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321
  17. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240:205–213
  18. Akritas MG, Arnold SF, Brunner E. Nonparametric hypothesis and rank statistics for unbalanced factorial designs. J Am Stat Assoc. 1997;92:258–265
  19. Aloia T, Sebagh M, Plasse M, Karam V, Levi F, Giacchetti S, et al. Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases. J Clin Oncol. 2006;24:4983–4990
  20. Ouaissi M, Moutardier V, Ramuz O, Cherki S, Lelong B, Turrini O, et al. Preoperative systemic chemotherapy does not modify strategy of liver resection. Hepatogastroenterology. 2006;53:405–408

PII: S0039-6060(09)00052-X

doi: 10.1016/j.surg.2009.01.004

Surgery
Volume 147, Issue 2 , Pages 185-194 , February 2010

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