Surgery
Volume 146, Issue 2 , Pages 155-165 , August 2009

Orally administered nitrite attenuates cardiac allograft rejection in rats

  • Jianghua Zhan, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • Department of Surgery, Tianjin Children's Hospital, Tianjin, China
    • ,
  • Atsunori Nakao, MD, PhD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Ryujiro Sugimoto, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Rajeev Dhupar, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Yinna Wang, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Zhiliang Wang, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Timothy R. Billiar, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • ,
  • Kenneth R. McCurry, MD

      Affiliations

    • Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
    • Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH
    • Corresponding Author InformationReprint requests: Kenneth R. McCurry, MD, Heart and Vascular Institute Cleveland Clinic, 9500 Euclid Avenue, J4-1, Cleveland, OH 44195.

,Accepted 12 May 2009.

References 

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  3. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, et al. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006;291:379–384
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  14. Tricker AR, Preussmann R. Carcinogenic N-nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat Res. 1991;259:277–289
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  17. Blesson S, Thiery J, Gaudin C, Stancou R, Kolb JP, Moreau JL, et al. Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO. Int Immunol. 2002;14:1169–1178
  18. Pieper GM, Roza AM. The complex role of iNOS in acutely rejecting cardiac transplants. Free Radic Biol Med. 2008;44:1536–1552
  19. Gianetti J, Del Sarto P, Bevilacqua S, Vassalle C, De Filippis R, Kacila M, et al. Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation. J Thorac Cardiovasc Surg. 2004;127:44–50
  20. Xia Y, Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc Natl Acad Sci U S A. 1997;94:6954–6958
  21. Bryan NS, Fernandez BO, Bauer SM, Garcia-Saura MF, Milsom AB, Rassaf T, et al. Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol. 2005;1:290–297
  22. Basu S, Azarova NA, Font MD, King SB, Hogg N, Gladwin MT, et al. Nitrite reductase activity of cytochrome c. J Biol Chem. 2008;283:32590–32597
  23. Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, et al. Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res. 2008;103:957–964
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 J.Z. and A.N. contributed equally to this work.

PII: S0039-6060(09)00235-9

doi: 10.1016/j.surg.2009.05.002

Surgery
Volume 146, Issue 2 , Pages 155-165 , August 2009

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