Surgery
Volume 146, Issue 2 , Pages 198-205 , August 2009

MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells

  • Yue Wang, PhD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Meijing Wang, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Aaron M. Abarbanell, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Brent R. Weil, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Jeremy L. Herrmann, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Jiangning Tan, MD, PhD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Nathan M. Novotny, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Arthur C. Coffey, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Daniel R. Meldrum, MD

      Affiliations

    • Clarian Cardiovascular Surgery, Indiana University School of Medicine, Indianapolis, IN
    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN
    • Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN
    • Corresponding Author InformationReprint requests: Daniel R. Meldrum, MD, 635 Barnhill Drive, Van Nuys Medical Science Building, Room 2017, Indianapolis, IN 46202.

,Accepted 11 April 2009.

References 

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  16. Crisostomo PR, Wang Y, Markel TA, Wang M, Lahm T, Meldrum DR. Human mesenchymal stem cells stimulated by TNF-{alpha}, LPS, or hypoxia produce growth factors by an NF{kappa}B- but not JNK-dependent mechanism. Am J Physiol Cell Physiol. 2008;294:C675–C682
  17. Ait-Ali D, Turquier V, Tanguy Y, Thouennon E, Ghzili H, Mounien L, et al. Tumor necrosis factor (TNF)-{alpha} persistently activates nuclear factor-{kappa}B signaling through the type 2 TNF receptor in chromaffin cells: implications for long-term regulation of neuropeptide gene expression in inflammation. Endocrinology. 2008;149:2840–2852
  18. Scherschel JA, Soonpaa MH, Srour EF, Field LJ, Rubart M. Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes when transplanted into peri-infarct myocardium. Mol Ther. 2008;16:1129–1137
  19. Tracey KJ, Cerami A. Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol. 1993;9:317–343
  20. Iosif RE, Ekdahl CT, Ahlenius H, Pronk CJ, Bonde S, Kokaia Z, et al. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci. 2006;26:9703–9712
  21. Markel TA, Crisostomo PR, Wang M, Herring CM, Meldrum DR. Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production. Am J Physiol Gastrointest Liver Physiol. 2007;293:G657–G662
  22. Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel ULM. TNF mediated neuroprotection against glutamate induced excitotoxicity is enhanced by NMDA receptor activation: Essential role of a TNF receptor 2 mediated, PI3 kinase dependent NF-kB pathway. J Biol Chem. 2004;279:32869–32881
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  24. Xu Q, Briggs J, Park S, Niu G, Kortylewski M, Zhang S, et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene. 2005;24:5552–5560

 Supported by Grants NIH R01GM070628, NIH R01HL085595, NIH K99/R00 HL0876077-01, NIH F32 HL092718-01, NIH F32 HL092719-01, and F32 HL093987-01A1.

PII: S0039-6060(09)00263-3

doi: 10.1016/j.surg.2009.04.013

Surgery
Volume 146, Issue 2 , Pages 198-205 , August 2009

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