Prognostic implications of tumor invasion or adhesion to peripancreatic vessels in resected pancreatic cancer
Accepted 4 April 2009. published online 16 July 2009.
Background
The purpose of this study was to evaluate the operative risk and the prognostic implications of pancreatectomy plus resection and reconstruction of peripancreatic vessels (PPV) in patients with pancreatic adenocarcinoma.
Methods
One hundred ten patients who underwent pancreatectomy with PPV resection and reconstruction (Study Group; SG) were retrospectively compared with 62 patients without distant metastasis who were palliated, (Control Group 1; CG-1), as well as 197 patients who underwent “conventional”pancreatectomy (Control Group 2; CG-2).
Results
Postoperative morbidity and mortality were similar in SG (33% and 3%), in CG-1 (26% and 3%), and in CG-2 (40% and 6%) patients. Median survival time (MST) of SG patients (15 months) was longer than that of CG-1 patients (6 months; P < .0001) and similar to that of CG-2 patients (18 months). Patients undergoing isolated venous resection (n = 84) had the best outcome (MST: 15 months) ( P < .0001 vs CG-1 patients), while patients undergoing resection of multiple PPV (n = 14) had the worst outcome (MST: 8 months). PPV infiltration, histologically proven in 64 patients (65%), was associated with decreased MST only if the tunica intima was infiltrated (26%) (11 months; P < .001). Multivariate analysis showed that no adjuvant therapy, intimal invasion, and poorly differentiated histology were associated with a higher hazard of death by 2.2, 2.2, and 2.5-fold, respectively.
Conclusion
In properly selected patients, pancreatectomy plus resection and reconstruction of PPV was performed as safely as palliation or “conventional” pancreatectomy and was associated with better survival when compared to palliation.
aDivisione di Chirurgia Generale e Trapianti nell'Uremico e nel Diabetico, Pisa, Italy
bDivisione di Anestesia e Rianimazione, Pisa, Italy
cDivisione di Radiologia Diagnostica e Interventistica, Pisa, Italy
dDivisione di Anatomia Patologica Sperimentale, Pisa, Italy
eDivisione di Chirurgia Generale 1 Universitaria, Pisa, Italy
Reprint requests: Ugo Boggi, MD, Azienda Ospedaliero-Universitaria Pisana, Divisione di Chirurgia Generale e Trapianti nell'Uremico e nel Diabetico, Dipartimento di Oncologia, Divsione di Chirurgia Generale, Ospedale di Cisanello Via Paradisa 2, 56124 Pisa, Italy.
ABSTRACT