Surgery
Volume 146, Issue 5 , Pages 950-954 , November 2009

Reciprocal gut–brain evolutionary symbiosis provokes and amplifies the postinjury systemic inflammatory response syndrome

  • Mark Lyte, PhD, MS, MT(ASCP)

      Affiliations

    • Corresponding Author InformationReprint requests: Mark Lyte, PhD, MS, MT(ASCP), Department of Pharmacy Practice, School of Pharmacy, Texas Tech University Health Sciences Center, 3601 4th Street, Mail Stop 8162, Lubbock, TX 79430.

,Accepted 3 June 2009.

References 

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  3. Lyte M, Bailey MT. Neuroendocrine-bacterial interactions in a neurotoxin-induced model of trauma. J Surg Res. 1997;70:195–201
  4. Alverdy JC, Chang EB. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away. J Leukoc Biol. 2008;83:461–466
  5. Goehler LE, Gaykema RP, Opitz N, Reddaway R, Badr N, Lyte M. Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni. Brain Behav Immun. 2005;19:334–344
  6. Wang X, Wang BR, Zhang XJ, Xu Z, Ding YQ, Ju G. Evidences for vagus nerve in maintenance of immune balance and transmission of immune information from gut to brain in STM-infected rats. World J Gastroenterol. 2002;8:540–545
  7. Berthoud HR. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil. 2008;20(Suppl 1):64–72
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  9. Kotzampassi K, Giamarellos-Bourboulis EJ, Voudouris A, Kazamias P, Eleftheriadis E. Benefits of a synbiotic formula (Synbiotic 2000Forte) in critically ill trauma patients: early results of a randomized controlled trial. World J Surg. 2006;30:1848–1855
  10. Besselink MG, van Santvoort HC, Buskens E, Boermeester MA, van Goor H, Timmerman HM, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:651–659
  11. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001;345:1223–1229
  12. Deitch EA, Xu D, Kaise VL. Role of the gut in the development of injury- and shock-induced SIRS and MODS: the gut-lymph hypothesis, a review. Front Biosci. 2006;11:520–528
  13. Stoutenbeek CP, van Saene HK, Little RA, Whitehead A. The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial. Intensive Care Med. 2007;33:261–270

PII: S0039-6060(09)00301-8

doi: 10.1016/j.surg.2009.06.002

Surgery
Volume 146, Issue 5 , Pages 950-954 , November 2009

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