« Previous
Next »
Surgery
Volume 146, Issue 2
, Pages 206-212
, August 2009
Targeting the gut barrier: Identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell
References
- . The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg. 1999;178:449–453
- Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: Effects on tight junction structural proteins. Shock. 2009;31:416–422
- LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007;132:2383–2394
- Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol. 2006;291:G938–G949
- . Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings?. Surgery. 2002;131:241–244
- . Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma. 2007;62:818–828
- . Systemic not just mesenteric lymph causes acute lung injury following hemorrhagic shock. Surgery. 2008;144:686–693
- . Post-hemorrhagic shock mesenteric lymph lipids prime neutrophils for enhanced cytotoxicity via phospholipase A2. Shock. 2001;16:218–222
- . Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nat Med. 1996;2:299–305
- . In vivo selection and validation of liver-specific ligands using a new T7 phage peptide display system. Drug Deliv. 2007;14:357–369
- Synchronous selection of homing peptides for multiple tissues by in vivo phage display. FASEB J. 2006;20:979–981
- . Gene transfer to mammalian cells using genetically targeted filamentous bacteriophage. FASEB J. 1999;13:727–734
- . Identification of peptide sequences that induce the transport of phage across the gastrointestinal mucosal barrier. J Virol Methods. 2004;116:177–180
- . Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging. Nat Protoc. 2008;3:89–96
- . Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol. 2006;169:1901–1909
- A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol. 2007;179:4808–4820
- Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009;66:17–24
- . Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis. Shock. 2007;28:192–201
- . Receptor-mediated gene transfer by phage-display vectors: applications in functional genomics and gene therapy. Drug Discov Today. 2001;6:793–801
- . Enhanced phagemid particle gene transfer in camptothecin-treated carcinoma cells. Cancer Res. 2002;62:977–981
- . Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery. Cancer Res. 2007;67:10958–10965
- . Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells. J Biol Chem. 2008;283:11752–11762
- . Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. Pharm Res. 2005;22:1011–1037
- . Identification of ligands binding specifically to inflammatory intestinal mucosa using phage display. Clin Exp Pharmacol Physiol. 2007;34:286–289
- Role of p38 MAPK signaling in burn-induced intestinal barrier breakdown. J Surg Res. 2009;In press
Presented as an SUS oral presentation at the 4th Annual Academic Surgical Congress, Fort Myers, Florida, February 4–6, 2009.
PII: S0039-6060(09)00308-0
doi: 10.1016/j.surg.2009.05.007
© 2009 Mosby, Inc. All rights reserved.
« Previous
Next »
Surgery
Volume 146, Issue 2
, Pages 206-212
, August 2009
