Surgery
Volume 146, Issue 2 , Pages 206-212 , August 2009

Targeting the gut barrier: Identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell

,Accepted 3 May 2009.

References 

  1. Moore FA. The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg. 1999;178:449–453
  2. Costantini TW, Loomis H, Putnam JG, Drusinsky D, Deree J, Choi S, et al. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: Effects on tight junction structural proteins. Shock. 2009;31:416–422
  3. Schwarz BT, Wang F, Shen L, Clayburgh D, Su L, Wang Y, et al. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology. 2007;132:2383–2394
  4. Clark JA, Doelle SM, Halpern MD, Saunders TA, Holubec H, Dvorak K, et al. Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment. Am J Physiol Gastrointest Liver Physiol. 2006;291:G938–G949
  5. Deitch EA. Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings?. Surgery. 2002;131:241–244
  6. Deree J, de Campos T, Shenvi E, Loomis WH, Hoyt DB, Coimbra R. Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation. J Trauma. 2007;62:818–828
  7. Diebel LN, Liberati DM, Ledgerwood AM, Lucas CE. Systemic not just mesenteric lymph causes acute lung injury following hemorrhagic shock. Surgery. 2008;144:686–693
  8. Gonzalez RJ, Moore EE, Ciesla DJ, Meng X, Biffl WL, Silliman CC. Post-hemorrhagic shock mesenteric lymph lipids prime neutrophils for enhanced cytotoxicity via phospholipase A2. Shock. 2001;16:218–222
  9. Barry MA, Dower WJ, Johnston SA. Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nat Med. 1996;2:299–305
  10. Ludtke JJ, Sololoff AV, Wong SC, Zhang G, Wolff JA. In vivo selection and validation of liver-specific ligands using a new T7 phage peptide display system. Drug Deliv. 2007;14:357–369
  11. Kolonin MG, Sun J, Do KA, Vidal CI, Ji Y, Baggerly KA, et al. Synchronous selection of homing peptides for multiple tissues by in vivo phage display. FASEB J. 2006;20:979–981
  12. Larocca D, Kassner PD, Witte A, Ladner RC, Pierce GF, Baird A. Gene transfer to mammalian cells using genetically targeted filamentous bacteriophage. FASEB J. 1999;13:727–734
  13. Duerr DM, White SJ, Schluesener HJ. Identification of peptide sequences that induce the transport of phage across the gastrointestinal mucosal barrier. J Virol Methods. 2004;116:177–180
  14. Cai W, Chen X. Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging. Nat Protoc. 2008;3:89–96
  15. Turner JR. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am J Pathol. 2006;169:1901–1909
  16. Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, et al. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol. 2007;179:4808–4820
  17. Costantini TW, Loomis WH, Putnam JG, Kroll L, Eliceiri BP, Baird A, et al. Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase. J Trauma. 2009;66:17–24
  18. Mazzon E, Cuzzocrea S. Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis. Shock. 2007;28:192–201
  19. Larocca D, Baird A. Receptor-mediated gene transfer by phage-display vectors: applications in functional genomics and gene therapy. Drug Discov Today. 2001;6:793–801
  20. Burg MA, Jensen-Pergakes K, Gonzalez AM, Ravey P, Baird A, Larocca D. Enhanced phagemid particle gene transfer in camptothecin-treated carcinoma cells. Cancer Res. 2002;62:977–981
  21. Lee TY, Lin CT, Kuo SY, Chang DK, Wu HC. Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery. Cancer Res. 2007;67:10958–10965
  22. Nishimura S, Takahashi S, Kamikatahira H, Kuroki Y, Jaalouk DE, O'Brien S. Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells. J Biol Chem. 2008;283:11752–11762
  23. Johanson CE, Duncan JA, Stopa EG, Baird A. Enhanced prospects for drug delivery and brain targeting by the choroid plexus-CSF route. Pharm Res. 2005;22:1011–1037
  24. Takagi T, Arisawa T, Yamamoto K, Hirata I, Nakano H, Sawada M. Identification of ligands binding specifically to inflammatory intestinal mucosa using phage display. Clin Exp Pharmacol Physiol. 2007;34:286–289
  25. Costantini TW, Peterson CY, Kroll LM, Loomis WH, Putnam JG, Eliceiri BP, et al. Role of p38 MAPK signaling in burn-induced intestinal barrier breakdown. J Surg Res. 2009;In press

 Presented as an SUS oral presentation at the 4th Annual Academic Surgical Congress, Fort Myers, Florida, February 4–6, 2009.

PII: S0039-6060(09)00308-0

doi: 10.1016/j.surg.2009.05.007

Surgery
Volume 146, Issue 2 , Pages 206-212 , August 2009