Surgery
Volume 146, Issue 2 , Pages 145-154 , August 2009

Acute postischemic treatment with estrogen receptor-α agonist or estrogen receptor-β agonist improves myocardial recovery

  • Nicholas D. Vornehm, MS

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Meijing Wang, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Aaron Abarbanell, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Jeremy Herrmann, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Brent Weil, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Jiangjing Tan, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Yue Wang, PhD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Megan Kelly, MS

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • ,
  • Daniel R. Meldrum, MD

      Affiliations

    • Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
    • Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN
    • Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN
    • Clarian Cardiovascular Surgery, Indiana University School of Medicine, Indianapolis, IN
    • Corresponding Author InformationReprint requests: Daniel R. Meldrum, MD, 635 Barnhill Drive MS 2017, Indianapolis, IN 46202.

,Accepted 17 April 2009.

References 

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  2. Lahm T, Crisostomo PR, Markel TA, Wang M, Weil BR, Novotny NM, et al. The effects of estrogen on pulmonary artery vasoreactivity and hypoxic pulmonary vasoconstriction: potential new clinical implications for an old hormone. Crit Care Med. 2008;36:2174–2183
  3. Wang M, Baker L, Tsai BM, Meldrum KK, Meldrum DR. Sex differences in the myocardial inflammatory response to ischemia-reperfusion injury. Am J Physiol Endocrinol Metab. 2005;288:E321–E326
  4. Wang M, Tsai BM, Reiger KM, Brown JW, Meldrum DR. 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J Mol Cell Cardiol. 2006;40:205–212
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  10. Booth EA, Obeid NR, Lucchesi BR. Activation of estrogen receptor-alpha protects the in vivo rabbit heart from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005;289:H2039–H2047
  11. Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, et al. 17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling. Circ Res. 2004;95:692–699
  12. Pelzer T, Jazbutyte V, Hu K, Segerer S, Nahrendorf M, Nordbeck P, et al. The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats. Cardiovasc Res. 2005;67:604–612
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  15. Kim JK, Pedram A, Razandi M, Levin ER. Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms. J Biol Chem. 2006;281:6760–6767
  16. Urata Y, Ihara Y, Murata H, Goto S, Koji T, Yodoi J, et al. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J Biol Chem. 2006;281:13092–13102
  17. Stefano GB, Prevot V, Beauvillain JC, Cadet P, Fimiani C, Welters I, et al. Cell-surface estrogen receptors mediate calcium-dependent nitric oxide release in human endothelia. Circulation. 2000;101:1594–1597
  18. Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, Liao JK. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 2000;407:538–541
  19. Pedram A, Razandi M, Levin ER. Nature of functional estrogen receptors at the plasma membrane. Mol Endocrinol. 2006;20:1996–2009
  20. Parkash J, Felty Q, Roy D. Estrogen exerts a spatial and temporal influence on reactive oxygen species generation that precedes calcium uptake in high-capacity mitochondria: implications for rapid nongenomic signaling of cell growth. Biochemistry. 2006;45:2872–2881
  21. Hsieh YC, Yu HP, Suzuki T, Choudhry MA, Schwacha MG, Bland KI, et al. Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage. J Mol Cell Cardiol. 2006;41:511–521
  22. Camper-Kirby D, Welch S, Walker A, Shiraishi I, Setchell KD, Schaefer E, et al. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res. 2001;88:1020–1027
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  24. Ozveri ES, Bozkurt A, Haklar G, Cetinel S, Arbak S, Yegen C, et al. Estrogens ameliorate remote organ inflammation induced by burn injury in rats. Inflamm Res. 2001;50:585–591

 Presented at the 4th Annual Academic Surgical Congress, Fort Myers, Florida, February 3–6, 2009.

 Supported in part by NIH R01GM070628 (D.R.M.), NIH K99 HL0876077 (M.W.), and NIH R01HL085595 (D.R.M.).

 N.D.V. and M.W. contributed equally to this work.

PII: S0039-6060(09)00312-2

doi: 10.1016/j.surg.2009.04.026

Surgery
Volume 146, Issue 2 , Pages 145-154 , August 2009

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