Surgery
Volume 146, Issue 2 , Pages 174-180 , August 2009

The negative effect of pretransplant overweight and obesity on the rate of improvement in physical quality of life after liver transplantation

  • Victor Zaydfudim, MD, MPH

      Affiliations

    • Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN
    • Corresponding Author InformationReprint requests: Victor Zaydfudim, MD, MPH, Department of Surgery, Vanderbilt University Medical Center, D-4314 Medical Center North, Nashville, TN 37232-2730.
    • ,
  • Irene D. Feurer, PhD

      Affiliations

    • Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN
    • Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Derek E. Moore, MD, MPH

      Affiliations

    • Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • Panarut Wisawatapnimit, MSN, PhD

      Affiliations

    • School of Nursing, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • J. Kelly Wright, MD

      Affiliations

    • Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN
    • ,
  • C. Wright Pinson, MBA, MD

      Affiliations

    • Department of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN

,Accepted 6 April 2009.

References 

  1. Hasse J. Pretransplant obesity: a weighty issue affecting transplant candidacy and outcomes. Nutr Clin Pract. 2007;22:494–504
  2. Leonard J, Heimbach JK, Malinchoc M, Watt K, Charlton M. The impact of obesity on long-term outcomes in liver transplant recipients-results of the NIDDK liver transplant database. Am J Transplant. 2008;8:667–672
  3. Pelletier SJ, Schaubel DE, Wei G, et al. Effect of body mass index on the survival benefit of liver transplantation. Liver Transpl. 2007;13:1678–1683
  4. Katz DA, McHorney CA, Atkinson RL. Impact of obesity on health-related quality of life in patients with chronic illness. J Gen Intern Med. 2000;15:789–796
  5. Hickman IJ, Jonsson JR, Prins JB, et al. Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut. 2004;53:413–419
  6. Pinson CW, Feurer ID, Payne JL, Wise PE, Shockley S, Speroff T. Health-related quality of life after different types of solid organ transplantation. Ann Surg. 2000;232:597–607
  7. Younossi ZM, McCormick M, Price LL, et al. Impact of liver transplantation on health-related quality of life. Liver Transpl. 2000;6:779–783
  8. Feurer ID, Moore DE, Speroff T, et al. Refining a health-related quality of life assessment strategy for solid organ transplant patients. Clin Transplant. 2004;18:39–45
  9. Ware JE, Kosinski M. Interpreting SF-36 summary health measures: a response. Qual Life Res. 2001;10:405–413discussion 415-420
  10. Ware JE, Kosinski M, Bayliss MS, McHorney CA, Rogers WH, Raczek A. Comparison of methods for the scoring and statistical analysis of SF-36 health profile and summary measures: summary of results from the Medical Outcomes Study. Med Care. 1995;33:AS264–AS279
  11. Desai R, Jamieson NV, Gimson AE, et al. Quality of life up to 30 years following liver transplantation. Liver Transpl. 2008;14:1473–1479
  12. Butler J, McCoin NS, Feurer ID, et al. Modeling the effects of functional performance and post-transplant comorbidities on health-related quality of life after heart transplantation. J Heart Lung Transplant. 2003;22:1149–1156
  13. Hoy HM. Comorbidities and health-related quality of life after lung transplantation. Doctoral dissertation. Nashville, TN: Vanderbilt University; 2008;
  14. McCulloch CE, Searle SR, Neuhaus JM. Generalized, linear and mixed models. 2nd ed.. New York: Wiley; 2008;
  15. van Ginneken BT, vandenBerg-Emons RJ, Kazemier G, Metselaar HJ, Tilanus HW, Stam HJ. Physical fitness, fatigue, and quality of life after liver transplantation. Eur J Appl Physiol. 2007;100:345–353
  16. Brown DW, Brown DR, Heath GW, et al. Associations between physical activity dose and health-related quality of life. Med Sci Sports Exerc. 2004;36:890–896
  17. Shaw K, Gennat H, O'Rourke P, DelMar C. Exercise for overweight or obesity. Cochrane Database Syst Rev. 2006;CD003817
  18. Shaw K, O'Rourke P, DelMar C, Kenardy J. Psychological interventions for overweight or obesity. Cochrane Database Syst Rev. 2005;CD003818
  19. Estraviz B, Quintana JM, Valdivieso A, et al. Factors influencing change in health-related quality of life after liver transplantation. Clin Transplant. 2007;21:481–499
  20. Dudley T, Chaplin D, Clifford C, Mutimer DJ. Quality of life after liver transplantation for hepatitis C infection. Qual Life Res. 2007;16:1299–1308
  21. Russell RT, Feurer ID, Wisawatapnimit P, Lillie ES, Castaldo ET, Pinson CW. Profile of health-related quality of life outcomes after liver transplantation: univariate effects and multivariate models. HPB. 2008;10:30–37
  22. Moore DE, Feurer ID, Speroff T, et al. Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg. 2005;140:273–277
  23. Mazuelos F, Abril J, Zaragoza C, et al. Cardiovascular morbidity and obesity in adult liver transplant recipients. Transplant Proc. 2003;35:1909–1910
  24. Toniutto P, Fabris C, Avellini C, et al. Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation. World J Gastroenterol. 2005;11:5944–5950

 Supported by the Institutional National Research Service Award T32 HS 013833 from the Agency of Healthcare Research and Quality, U.S. Department of Health and Human Services, and by a general educational award from the Novartis Pharmaceuticals Corporation.

 Presented at the 4th Annual Academic Surgical Congress, Fort Myers, Florida, February 3–5, 2009.

PII: S0039-6060(09)00329-8

doi: 10.1016/j.surg.2009.04.027

Surgery
Volume 146, Issue 2 , Pages 174-180 , August 2009

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