Surgery
Volume 147, Issue 1 , Pages 134-137, January 2010

Women rule

  • M. Kelley Bullard

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
    • Corresponding Author InformationReprint requests: M. Kelley Bullard, MD, Department of Surgery, UCSF-East Bay, 1411 East 31st Street, Oakland, CA 94602.
  • ,
  • Natasha Bir

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
  • ,
  • Rita Kwan

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
  • ,
  • Elizabeth Cureton

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
  • ,
  • Peggy Knudson

      Affiliations

    • Department of Surgery, University of California, San Francisco, San Francisco, CA
  • ,
  • Alden Harken

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA

Accepted 22 January 2008.

Female animals tolerate trauma and hemorrhage better than male animals

AND

Estrogen has rapid nongenomic effects that protect organs from damage and attenuate insult–induced inflammation

MOREOVER

The survival deficit from trauma and hemorrhage produced in ovariectomized female animals is repaired with administration of exogenous estrogen

AND

Women survive injury, sepsis, and trauma-hemorrhage–induced hypoxemia/reperfusion better than men

THEREFORE

Women rule … in survival after trauma, thus, men would benefit from being more like women.

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PII: S0039-6060(09)00349-3

doi:10.1016/j.surg.2009.04.033

Surgery
Volume 147, Issue 1 , Pages 134-137, January 2010