Surgery
Volume 147, Issue 1 , Pages 134-137 , January 2010

Women rule

  • M. Kelley Bullard

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
    • Corresponding Author InformationReprint requests: M. Kelley Bullard, MD, Department of Surgery, UCSF-East Bay, 1411 East 31st Street, Oakland, CA 94602.
    • ,
  • Natasha Bir

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
    • ,
  • Rita Kwan

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
    • ,
  • Elizabeth Cureton

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA
    • ,
  • Peggy Knudson

      Affiliations

    • Department of Surgery, University of California, San Francisco, San Francisco, CA
    • ,
  • Alden Harken

      Affiliations

    • Department of Surgery, University of California, San Francisco – East Bay, San Francisco, CA

,Accepted 22 January 2008.

References 

  1. Diodato MD, Knoferl MW, Schwacha MG, et al. Gender differences in the inflammatory response and survival following haemorrhage and subsequent sepsis. Cytokine. 2001;4:162–169
  2. Sperry J, Nathens A, Frankel H, et al. Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible?. Crit Care Med. 2008;36:1838–1845
  3. Wichmann MW, Zellweger R, DeMaso CM, et al. Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation. Cytokine. 1996;8:853–863
  4. Yu H, Chaudry I. The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhage. Shock. 2009;31:227–237
  5. Straub R. The complex role of estrogens in inflammation. Endocr Rev. 2007;28:521–574
  6. Angele M, Wichmann M, Ayala A, et al. Testosterone receptor blockade after hemorrhage in males: restoration of the depressed immune functions and improved survival following subsequent sepsis. Arch Surg. 1997;132:1207–1214
  7. Frink M, Pape H-C, Griensven Mv, et al. Influence of sex and age on MODS and cytokines after multiple injuries. Shock. 2007;27:151–156
  8. Choudhry M, Chaudry I. 17beta-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage. J Leukoc Biol. 2008;83:518–522
  9. Moriarity K, Kim K, Bender J. Estrogen receptor-mediated rapid signaling. Endocrinology. 2006;147:5557–5563
  10. Guerra S, Leri A, Wang X, et al. Myocyte death in the failing human heart is gender dependent. Circ Res. 1999;85:856–866
  11. Wang M, Crisostomo P, Markel T, et al. Estrogen receptor-beta mediates acute myocardial protection following ischemia. Surgery. 2008;144:233–238
  12. Booth EA, Maier R, Marchesi , et al. The pathway-selective estrogen receptor ligand WAY-169916 reduces infarct size after myocardial ischemia and reperfusion by an estrogen receptor dependent mechanism. J Cardiovasc Pharmacol. 2007;49:401–407

PII: S0039-6060(09)00349-3

doi: 10.1016/j.surg.2009.04.033

Surgery
Volume 147, Issue 1 , Pages 134-137 , January 2010

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