Surgery
Volume 146, Issue 4 , Pages 543-553 , October 2009

The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: The untold story

  • Anton I. Skaro, MD, PhD

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • Corresponding Author InformationReprint requests: Anton I. Skaro, MD, PhD, Division of Organ Transplantation, Northwestern University, Feinberg School of Medicine, Galter Pavilion 17-200, Chicago, IL 60611.
    • ,
  • Colleen L. Jay, MD

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Talia B. Baker, MD

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Edward Wang, PhD

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Sarina Pasricha, BS

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Vadim Lyuksemburg, BS

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • John A. Martin, MD

      Affiliations

    • Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Joseph M. Feinglass, PhD

      Affiliations

    • Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Luke B. Preczewski

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL
    • ,
  • Michael M. Abecassis, MD, MBA

      Affiliations

    • Division of Organ Transplantation, Feinberg School of Medicine, Northwestern University, Chicago, IL

,Accepted 9 June 2009.

References 

  1. Pomfret EA, Sung RS, Allan J, et al. Solving the organ shortage crisis: the 7th annual American Society of Transplant Surgeons' State-of-the-Art Winter Symposium. Am J Transplant. 2008;8:745–752
  2. Freeman RB, Steffick DE, Guidinger MK, et al. Liver and intestine transplantation in the United States, 1997-2006. Am J Transplant. 2008;8:958–976
  3. Medicare and Medicaid programs; conditions for coverage for organ procurement organizations (OPOs). Final rule. Fed Reg. 2006;71:30981–31054
  4. Whiting JF, Delmonio F, Morrissey P, et al. Clinical results of an organ procurement organization effort to increase utilization of donors after cardiac death. Transplantation. 2006;81:1368–1371
  5. Merion RM, Pelletier SJ, Goodrich N, et al. Donation after cardiac death as a strategy to increase deceased donor liver availability. Ann Surg. 2006;244:555–562
  6. D'Alessandro AM, Hoffman RM, Knechtle SJ, et al. Successful extrarenal transplantation from non-heart-beating donors. Transplantation. 1995;59:977–982
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  8. Fujita S, Mizuno S, Fujikawa T, et al. Liver transplantation from donation after cardiac death: a single center experience. Transplantation. 2007;84:46–49
  9. Foley DP, Fernandez LA, Leverson G, et al. Donation after cardiac death: the University of Wisconsin experience with liver transplantation. Ann Surg. 2005;242:724–731
  10. Abt PL, Desai NM, Crawford MD, et al. Survival following liver transplantation from non-heart-beating donors. Ann Surg. 2004;239:87–92
  11. Abt P, Crawford M, Desai N, et al. Liver transplantation from controlled non-heart-beating donors: an increased incidence of biliary complications. Transplantation. 2003;75:1659–1663
  12. Chan EY, Olson LC, Kisthard JA, et al. Ischemic cholangiopathy following liver transplantation from donation after cardiac death donors. Liver Transpl. 2008;14:604–610
  13. Lee KW, Simpkins CE, Montgomery RA, et al. Factors affecting graft survival after liver transplantation from donation after cardiac death donors. Transplantation. 2006;82:1683–1688
  14. Manzarbeitia CY, Ortiz JA, Jeon H, et al. Long-term outcome of controlled, non-heart-beating donor liver transplantation. Transplantation. 2004;78:211–215
  15. D'Alessandro AM, Fernandex LA, Chin LT, et al. Donation after cardiac death: the University of Wisconsin experience. Ann Transplant. 2004;9:68–71
  16. Doshi MD, Hunsicker LG. Short- and long-term outcomes with the use of kidneys and livers donated after cardiac death. Am J Transplant. 2007;7:122–129
  17. Mateo R, Cho T, Singh G, et al. Risk factors for graft survival after liver transplantation from donation after cardiac death donors: an analysis of OPTN/UNOS data. Am J Transplant. 2006;6:791–796
  18. Maheshwari A, Maley W, Li Z, et al. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl. 2007;13:1645–1653
  19. Kaczmarek B, Manas MD, Jaques BC, et al. Ischemic cholangiopathy after liver transplantation from controlled non-heart-beating donors-a single-center experience. Transplant Proc. 2007;39:2793–2795
  20. Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant. 2006;6:783–790
  21. Reich DJ, Munoz SJ, Rothstein KD, et al. Controlled non-heart-beating donor liver transplantation: a successful single center experience, with topic update. Transplantation. 2000;70:1159–1166
  22. Yagci G, Fernandez LA, Knechtle SJ, et al. The impact of donor variables on the outcome of orthotopic liver transplantation for hepatitis C. Transplant Proc. 2008;40:219–223
  23. Selck FW, Grossman EB, Ranter LE, et al. Utilization, outcomes, and retransplantation of liver allografts from donation after cardiac death: implications for further expansion of the deceased-donor pool. Ann Surg. 2008;248:599–607
  24. Deltenre P, Valla DC. Ischemic cholangiopathy. J Hepatol. 2006;44:806–817
  25. Englesbe MJ, Dimick J, Mathur A, et al. Who pays for biliary complications following liver transplant? A business case for quality improvement. Am J Transplant. 2006;6:2978–2982
  26. Stewart ZA, Cameron AM, Singer AL, et al. Histidine-tryptophan-ketoglutarate (HTK) is associated with reduced graft survival in deceased donor livers, especially those donated after cardiac death. Am J Transplant. 2009;9:286–293

 Research for this paper was done while the author (C.J.) was a National Research Service Award postdoctoral fellow with the Division of Organ Transplantation at Northwestern University, Feinberg School of Medicine under an institutional award from the National Institute of Diabetes and Digestive and Kidney Diseases, 5 T32 DK077662-02 (PI: Michael Abecassis, MD MBA).

 A.I.S. and C.L.J. contributed equally to this manuscript.

PII: S0039-6060(09)00476-0

doi: 10.1016/j.surg.2009.06.052

Surgery
Volume 146, Issue 4 , Pages 543-553 , October 2009

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