Surgery
Volume 147, Issue 2 , Pages 303-309 , February 2010

The utility of [11C] dihydrotetrabenazine positron emission tomography scanning in assessing β-cell performance after sleeve gastrectomy and duodenal-jejunal bypass

Presented at the 2009 meeting of the Society of University Surgeons.

  • William B. Inabnet, MD

      Affiliations

    • Division of Metabolic, Endocrine and Minimally Invasive Surgery. Department of Surgery, Mount Sinai Medical Center, New York, NY
    • Corresponding Author InformationReprint requests: William B. Inabnet, MD, Chief, Division of Metabolic, Endocrine and Minimally Invasive Surgery, Mount Sinai Medical Center, 5 East 98th Street, Box 1259, New York, NY 10029.
    • ,
  • Luca Milone, MD

      Affiliations

    • Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Paul Harris, MD

      Affiliations

    • Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Evren Durak, MD

      Affiliations

    • Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Matthew J. Freeby, MD

      Affiliations

    • Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Leaque Ahmed, MD

      Affiliations

    • Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Manu Sebastian, MD

      Affiliations

    • Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Jean-Christophe Lifante, MD

      Affiliations

    • Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Marc Bessler, MD

      Affiliations

    • Division of Gastrointestinal and Endocrine Surgery, Department of Surgery, College of Physicians and Surgeons of Columbia University, New York, NY
    • ,
  • Judith Korner, MD, PhD

      Affiliations

    • Division of Endocrinology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY

,Accepted 20 August 2009.

References 

  1. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world–a growing challenge. N Engl J Med. 2007;356:213–215
  2. Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord. 1998;22:39–47
  3. Kral JG. Morbidity of severe obesity. Surg Clin North Am. 2001;81:1039–1061
  4. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753–761
  5. Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg. 1995;222:339–350
  6. Ponce J, Haynes B, Paynter S, et al. Effect of Lap-Band-induced weight loss on type 2 diabetes mellitus and hypertension. Obes Surg. 2004;14:1335–1342
  7. Torquati A, Lutfi R, Abumrad N, Richards WO. Is Roux-en-Y gastric bypass surgery the most effective treatment for type 2 diabetes mellitus in morbidly obese patients?. J Gastrointest Surg. 2005;9:1112–1116
  8. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–1737
  9. Dixon JB, O'Brien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA. 2008;299:316–323
  10. Schauer PR, Burguera B, Ikramuddin S, et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus. Ann Surg. 2003;238:467–484
  11. Simpson NR, Souza F, Witkowski P, et al. Visualizing pancreatic beta-cell mass with [11C]DTBZ. Nucl Med Biol. 2006;33:855–864
  12. Souza F, Simpson N, Raffo A, et al. Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model. J Clin Invest. 2006;116:1506–1513
  13. Rubino F, Marescaux J. Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease. Ann Surg. 2004;239:1–11
  14. Conybeare G, Leslie GB. Improved oral dosing technique for rats. J Pharmacol Methods. 1988;19:109–116
  15. Inabnet WB, Milone L, Korner J, et al. A rodent model of metabolic surgery for study of type 2 diabetes and positron emission tomography scanning of beta cell mass. Surg Obes Relat Dis. 2009;5:212–217
  16. Pacheco D, de Luis DA, Romero A, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surg. 2007;194:221–224
  17. Rubino F, Forgione A, Cummings DE, et al. The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes. Ann Surg. 2006;244:741–749
  18. Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–1705
  19. Korner J, Bessler M, Inabnet W, et al. Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Surg Obes Relat Dis. 2007;3:597–601
  20. Melissas J, Koukouraki S, Askoxylakis J, et al. Sleeve gastrectomy: a restrictive procedure?. Obes Surg. 2007;17:57–62
  21. Ilias I, Chen CC, Carrasquillo JA, et al. Comparison of 6-18F-fluorodopamine PET with 123I-metaiodobenzylguanidine and 111In-pentetreotide scintigraphy in localization of nonmetastatic and metastatic pheochromocytoma. J Nucl Med. 2008;49:1613–1619
  22. Movassat J, Calderari S, Fernandez E, et al. Type 2 diabetes—a matter of failing beta-cell neogenesis? Clues from the GK rat model. Diabetes Obes Metab. 2007;9(Suppl 2):187–195
  23. Momose K, Nunomiya S, Nakata M, et al. Immunohistochemical and electron-microscopic observation of beta-cells in pancreatic islets of spontaneously diabetic Goto-Kakizaki rats. Med Mol Morphol. 2006;39:146–153

 Funded by a Covidien Healthcare research grant, Columbia University Department of Surgery Research grant.

 The research was performed while Dr Inabnet was affiliated with Columbia University, New York, NY.

PII: S0039-6060(09)00501-7

doi: 10.1016/j.surg.2009.08.005

Surgery
Volume 147, Issue 2 , Pages 303-309 , February 2010

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