Surgery
Volume 146, Issue 6 , Pages 1073-1080 , December 2009

Distinct loci on chromosome 1q21 and 6q22 predispose to familial nonmedullary thyroid cancer: A SNP array-based linkage analysis of 38 families

  • Insoo Suh, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • ,
  • Sebastiano Filetti, MD

      Affiliations

    • Department of Medicine, Sapienza University of Rome, Rome, Italy
    • ,
  • Menno R. Vriens, MD, PhD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • ,
  • Marlon A. Guerrero, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • ,
  • Salvatore Tumino, MD

      Affiliations

    • Department of Biomedical Sciences, University of Catania, Catania, Italy
    • ,
  • Mariwil Wong, BS

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • ,
  • Wen T. Shen, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • ,
  • Electron Kebebew, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • ,
  • Quan-Yang Duh, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • Surgical Service, Veterans Affairs Medical Center, San Francisco, CA
    • ,
  • Orlo H. Clark, MD

      Affiliations

    • Department of Surgery, University of California, San Francisco, CA
    • Corresponding Author InformationReprint requests: Orlo H. Clark, MD, Department of Surgery, UCSF-Mount Zion Medical Center. 1600 Divisadero Street, Box 1674, Hellman Building, Room C-347, San Francisco, CA 94143-1674.

,Accepted 17 September 2009.

References 

  1. Grossman RF, Tu SH, Duh QY, Siperstein AE, Novosolov F, Clark OH. Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive treatment. Arch Surg. 1995;130:892–897
  2. Loh KC. Familial nonmedullary thyroid carcinoma: a meta-review of case series. Thyroid. 1997;7:107–113
  3. Capezzone M, Marchisotta S, Cantara S, Busonero G, Brilli L, Pazaitou-Panayiotou K, et al. Familial non-medullary thyroid carcinoma displays the features of clinical anticipation suggestive of a distinct biological entity. Endocr Relat Cancer. 2008;15:1075–1081
  4. Alsanea O, Wada N, Ain K, Wong M, Taylor K, Ituarte PH, et al. Is familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series. Surgery. 2000;128:1043–1050
  5. Sippel RS, Caron NR, Clark OH. An evidence-based approach to familial nonmedullary thyroid cancer: screening, clinical management, and follow-up. World J Surg. 2007;31:924–933
  6. Uchino S, Noguchi S, Kawamoto H, Yamashita H, Watanabe S, Yamashita H, et al. Familial nonmedullary thyroid carcinoma characterized by multifocality and a high recurrence rate in a large study population. World J Surg. 2002;26:897–902
  7. Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Hoff AO, et al. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid. 2005;15:531–544
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  9. Canzian F, Amati P, Harach HR, Kraimps JL, Lesueur F, Barbier J, et al. A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. Am J Hum Genet. 1998;63:1743–1748
  10. Malchoff CD, Sarfarazi M, Tendler B, Forouhar F, Whalen G, Joshi V, et al. Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. J Clin Endocrinol Metab. 2000;85:1758–1764
  11. McKay JD, Lesueur F, Jonard L, Pastore A, Williamson J, Hoffman L, et al. Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21. Am J Hum Genet. 2001;69:440–446
  12. Cavaco BM, Batista PF, Sobrinho LG, Leite V. Mapping a new familial thyroid epithelial neoplasia susceptibility locus to chromosome 8p23.1-p22 by high-density single-nucleotide polymorphism genome-wide linkage analysis. J Clin Endocrinol Metab. 2008;93:4426–4430
  13. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin–rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet. 2002;30:97–101
  14. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet. 1997;61:1179–1188
  15. Pal T, Vogl FD, Chappuis PO, Tsang R, Brierley J, Renard H, et al. Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer: a hospital-based study. J Clin Endocrinol Metab. 2001;86:5307–5312
  16. Sturgeon C, Clark OH. Familial nonmedullary thyroid cancer. Thyroid. 2005;15:588–593
  17. Charkes ND. On the prevalence of familial nonmedullary thyroid cancer in multiply affected kindreds. Thyroid. 2006;16:181–186
  18. Triponez F, Wong M, Sturgeon C, Caron N, Ginzinger DG, Segal MR, et al. Does familial non-medullary thyroid cancer adversely affect survival?. World J Surg. 2006;30:787–793
  19. Ma NF, Hu L, Fung JM, Xie D, Zheng BJ, Chen L, et al. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology. 2008;47:503–510
  20. Willis TG, Zalcberg IR, Coignet LJ, Wlodarska I, Stul M, Jadayel DM, et al. Molecular cloning of translocation t(1;14) (q21;q32) defines a novel gene (BCL9) at chromosome 1q21. Blood. 1998;91:1873–1881
  21. Vandepoele K, Van Roy N, Staes K, Speleman F, van Roy F. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. Mol Biol Evol. 2005;22:2265–2274
  22. Gudmundsson J, Sulem P, Gudbjartsson DF, Jonasson JG, Sigurdsson A, Bergthorsson JT, et al. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. Nat Genet. 2009;41:460–464
  23. Brunaud L, Zarnegar R, Wada N, Magrane G, Wong M, Duh QY, et al. Chromosomal aberrations by comparative genomic hybridization in thyroid tumors in patients with familial nonmedullary thyroid cancer. Thyroid. 2003;13:621–629
  24. Prazeres HJ, Rodrigues F, Soares P, Naidenov P, Figueiredo P, Campos B, et al. Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma. Fam Cancer. 2008;7:141–149
  25. Xing M. The T1799A BRAF mutation is not a germline mutation in familial nonmedullary thyroid cancer. Clin Endocrinol (Oxf). 2005;63:263–266

 Supported by Helen and Sanford Diller Foundation, Heller Family Foundation, Grove Foundation, Friends of Endocrine Surgery.

PII: S0039-6060(09)00541-8

doi: 10.1016/j.surg.2009.09.012

Surgery
Volume 146, Issue 6 , Pages 1073-1080 , December 2009

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