Surgery
Volume 146, Issue 6 , Pages 1099-1104, December 2009

Incidental papillary carcinoma in patients treated surgically for benign thyroid diseases

  • Dawn P. Bradly, MD

      Affiliations

    • Rush University Medical Center, Department of Pathology, Chicago, IL
    • Corresponding Author InformationReprint requests: Dawn P. Bradly, MD, Department of Pathology, Rush University Medical Center, 1750 W. Harrison Street, 570 Jelke, Chicago, IL 60612.
    • ,
  • Vijaya Reddy, MD

      Affiliations

    • Rush University Medical Center, Department of Pathology, Chicago, IL
    • ,
  • Richard A. Prinz, MD

      Affiliations

    • Rush University Medical Center, Department of General Surgery, Chicago, IL
    • ,
  • Paolo Gattuso, MD

      Affiliations

    • Rush University Medical Center, Department of Pathology, Chicago, IL

Accepted 24 September 2009.

Background

The frequency of incidental papillary carcinoma (IPC) has been reported to be between 4.6 % and 10% in operatively treated benign thyroid diseases. This study reviews the occurrence of IPC in thyroid glands removed for benign disease at our institution.

Methods

Six hundred and seventy-eight patients underwent partial or total thyroidectomy for benign thyroid diseases. The incidence of IPC was compared among patients with Hashimoto's thyroiditis, multinodular goiter, follicular adenoma, and Graves' disease.

Results

Overall, 81 (12.0%) IPCs were recorded with decreasing order of frequency: Hashimoto's thyroiditis, follicular adenoma, goiter, and Graves' disease. Contralateral IPC was detected in 6/15 (40%) patients with follicular adenoma.

Conclusion

The overall incidence of IPC in benign operatively resected thyroid disease was 12%. Hashimoto's thyroiditis had the greatest rate of IPC. IPC was encountered in the contralateral lobe in 40% of patients with follicular adenoma. The association of IPCs with Hashimoto's thyroiditis may indicate a link to thyroid cancer. Total thyroidectomy may be considered an appropriate operative treatment in patients with Hashimoto's thyroiditis and follicular adenoma requiring operation owing to the high incidence and frequent contralateral involvement of IPC, respectively.

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PII: S0039-6060(09)00566-2

doi:10.1016/j.surg.2009.09.025

Surgery
Volume 146, Issue 6 , Pages 1099-1104, December 2009

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