Surgery
Volume 147, Issue 3 , Pages 378-391 , March 2010

Peritoneal adhesion formation and reformation tracked by sequential laparoscopy: Optimizing the time point for adhesiolysis

  • Verónica Gómez-Gil, PhD

      Affiliations

    • Department of Medical Specialities, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain
    • ,
  • Natalio García-Honduvilla, PhD

      Affiliations

    • Department of Medical Specialities, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain
    • ,
  • Gemma Pascual, PhD

      Affiliations

    • Department of Medical Specialities, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain
    • ,
  • Marta Rodríguez, PhD

      Affiliations

    • Department of Surgery, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain
    • ,
  • Julia Buján, MD, PhD

      Affiliations

    • Department of Medical Specialities, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain
    • ,
  • Juan M. Bellón, MD, PhD

      Affiliations

    • Department of Surgery, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), University of Alcalá, Alcalá de Henares, Madrid, Spain
    • Corresponding Author InformationReprint requests: Juan M. Bellón, MD, PhD, Department of Surgery, Faculty of Medicine, University of Alcalá, Ctra. Madrid-Barcelona, Km 33,600, 28871, Alcalá de Henares, Madrid, Spain.

,Accepted 5 October 2009.

References 

  1. Kavic SM, Kavic SM. Adhesions and adhesiolysis: the role of laparoscopy. JSLS. 2002;6:99–109
  2. Vrijland WW, Jeekel J, Van Geldorp HJ, Swank DJ, Bonjer HJ. Abdominal adhesions: intestinal obstruction, pain, and infertility. Surg Endosc. 2003;17:1017–1022
  3. Bellón JM, Contreras LA, Buján J, Jurado F. Effect of phosphatidylcholine on the process of peritoneal adhesion following implantation of a polypropylene mesh prosthesis. Biomaterials. 1996;17:1369–1372
  4. Bellón JM, Rodríguez M, García-Honduvilla N, Pascual G, Buján J. Efficiency of 4% icodextrin in preventing adhesions to spiral tacks used to fix intraperitoneal prostheses. Eur Surg Res. 2006;38:458–463
  5. Yeo Y, Kohane DS. Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm. 2008;68:57–66
  6. Tittel A, Treutner KH, Titkova S, Ottinger A, Schumpelick V. Comparison of adhesion reformation after laparoscopic and conventional adhesiolysis in an animal model. Langenbecks Arch Surg. 2001;386:141–145
  7. Luciano DE, Roy G, Luciano AA. Adhesion reformation after laparoscopic adhesiolysis: where, what type, and in whom they are most likely to recur. J Minim Invasive Gynecol. 2008;15:44–48
  8. Gutt CN, Oniu T, Schemmer P, Mehrabi A, Büchler MW. Fewer adhesions induced by laparoscopic surgery?. Surg Endosc. 2004;18:898–906
  9. Holmdahl L. The role of fibrinolysis in adhesion formation. Eur J Surg Suppl. 1997;577:24–31
  10. diZerega GS. Biochemical events in peritoneal tissue repair. Eur J Surg Suppl. 1997;577:10–16
  11. Chung DR, Chitnis T, Panzo RJ, Kasper DL, Sayegh MH, Tzianabos AO. CD4 + T cells regulate surgical and postinfectious adhesion formation. J Exp Med. 2002;195:1471–1478
  12. Binnebösel M, Rosch R, Junge D, Lynen-Jansen P, Schumpelick V, Klinge U. Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease. World J Surg. 2008;32:296–304
  13. Chegini N. TGF-beta system: the principal profibrotic mediator of peritoneal adhesion formation. Semin Reprod Med. 2008;26:298–312
  14. Cahill RA, Redmond HP. Cytokine orchestration in post-operative peritoneal adhesion formation. World J Gastroenterol. 2008;14:4861–4866
  15. Baptista ML, Bonsack ME, Felemovicius I, Delaney JP. Abdominal adhesions to prosthetic mesh evaluated by laparoscopy and electron microscopy. J Am Coll Surg. 2000;190:271–280
  16. Matthews BD, Pratt BL, Pollinger HS, Backus CL, Kercher KW, Sing RF, et al. Assessment of adhesion formation to intra-abdominal polypropylene mesh and polytetrafluoroethylene mesh. J Surg Res. 2003;114:126–132
  17. Felemovicius I, Bonsack ME, Hagerman G, Delaney JP. Prevention of adhesions to polypropylene mesh. J Am Coll Surg. 2004;198:543–548
  18. Bellón J, Contreras LA, Pascual G, Buján J. Evaluation of the acute scarring response to the implant of different types of biomaterial in the abdominal wall. J Mater Sci Mater Med. 2000;11:25–29
  19. Prushik SG, Aarons CB, Matteotti R, Reed KL, Gower AC, Leeman SE, et al. A neurokinin 1 receptor antagonist decreases adhesion reformation after laparoscopic lysis of adhesions in a rat model of adhesion formation. Surg Endosc. 2007;21:1790–1795
  20. Williams RS, Rossi AM, Chegini N, Schultz G. Effect of transforming growth factor beta on postoperative adhesion formation and intact peritoneum. J Surg Res. 1992;52:65–70
  21. Chegini N, Gold LI, Williams RS, Masterson BJ. Localization of transforming growth factor beta isoforms TGF-beta 1, TGF-beta 2, and TGF-beta 3 in surgically induced pelvic adhesions in the rat. Obstet Gynecol. 1994;83:449–454
  22. Chegini N. The role of growth factors in peritoneal healing: transforming growth factor beta (TGF-beta). Eur J Surg Suppl. 1997;577:17–23
  23. Ciark DA, Coker R. Transforming growth factor-beta (TGF-beta). Int J Biochem Cell Biol. 1998;30:293–298
  24. Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB. Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution. J Clin Invest. 1990;86:1976–1984
  25. Bennet NT, Schultz GS. Growth factors and wound healing: part II. Role in normal and chronic wound healing. Am J Surg. 1993;166:74–81
  26. diZerega GS. Peritoneum, peritoneal healing, and adhesion formation. In: Peritoneal Surgery. New York: Springer-Verlag; 2000;p. 3–37
  27. Gómez-Gil V, Pascual G, García-Honduvilla N, Rodríguez M, Buján J, Bellón JM. Characterizing omental adhesions by culturing cells isolated from a novel in vivo adhesion model. Wound Repair Regen. 2009;17:51–61
  28. Wilkosz S, Epstein J, de Giorgio-Miller A, McLean W, Ireland G, Herrick S. Remodelling of adipose tissue during experimental omental adhesion formation. Br J Surg. 2008;95:387–396
  29. Binnebösel M, Klinge U, Rosch R, Junge K, Lynen-Jansen P, Schumpelick V. Morphology, quality, and composition in mature human peritoneal adhesions. Langenbecks Arch Surg. 2008;393:59–66

PII: S0039-6060(09)00621-7

doi: 10.1016/j.surg.2009.10.011

Surgery
Volume 147, Issue 3 , Pages 378-391 , March 2010

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