Surgery
Volume 146, Issue 6 , Pages 1035-1041 , December 2009

Serum aldosterone is correlated positively to parathyroid hormone (PTH) levels in patients with primary hyperparathyroidism

  • Laurent Brunaud, MD

      Affiliations

    • Department of General, Digestive and Endocrine Surgery, University of Nancy, Vandoeuvre-les-Nancy, France
    • Corresponding Author InformationReprint requests: Laurent Brunaud, MD, Department of General, Digestive and Endocrine Surgery, CHU Nancy-Brabois (Hopital d'adultes), 11 allée du morvan, 54511 Vandoeuvre-les-Nancy, France.
    • ,
  • Adeline Germain, MD

      Affiliations

    • Department of General, Digestive and Endocrine Surgery, University of Nancy, Vandoeuvre-les-Nancy, France
    • ,
  • Rasa Zarnegar, MD

      Affiliations

    • Department of Surgery, Weill Cornell Medical College, New York, NY
    • ,
  • Marc Rancier, MD

      Affiliations

    • Department of Endocrinology, University of Nancy, Vandoeuvre-les-Nancy, France
    • ,
  • Saud Alrasheedi, MD

      Affiliations

    • Department of General, Digestive and Endocrine Surgery, University of Nancy, Vandoeuvre-les-Nancy, France
    • ,
  • Cecile Caillard, MD

      Affiliations

    • Department of Digestive and Endocrine Surgery, CHU Nantes, Nantes, France
    • ,
  • Ahmet Ayav, MD

      Affiliations

    • Department of General, Digestive and Endocrine Surgery, University of Nancy, Vandoeuvre-les-Nancy, France
    • ,
  • George Weryha, MD

      Affiliations

    • Department of Endocrinology, University of Nancy, Vandoeuvre-les-Nancy, France
    • ,
  • Eric Mirallie, MD

      Affiliations

    • Department of Digestive and Endocrine Surgery, CHU Nantes, Nantes, France
    • ,
  • Laurent Bresler, MD

      Affiliations

    • Department of General, Digestive and Endocrine Surgery, University of Nancy, Vandoeuvre-les-Nancy, France

,Accepted 17 September 2009.

References 

  1. Silverberg S, Lewiecki M, Mosekilde L, Peacock M, Rubin M. Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endoc Metab. 2009;94:351–365
  2. Vestergaard P, Mosekilde L. Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism. BMJ. 2003;327:530–535
  3. Procopio M, Magro G, Cesario F, Piovesan A, Pia A, Molineri N, et al. The oral glucose tolerance test reveals a high frequency of both impaired glucose tolerance and undiagnosed type 2 diabetes mellitus in primary hyperparathyroidism. Diabet Med. 2002;19:958–961
  4. Sancho JJ, Rouco J, Riera-Vidal R, Sitges-Serra A. Long-term effects of parathyroidectomy for primary hyperparathyroidism on arterial hypertension. World J Surg. 1992;16:732–735
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  7. Benetos A, Gardner J, Kimura M, Labat C, Nzietchueng R, Dousset B, et al. Aldosterone and telomere length in white blood cells. J Gerontol. 2005;12:1593–1596
  8. Schmieder R, Hilgers K, Schlaich MP, Schmidt BM. Renin-angiotensin system and cardiovascular risk. Lancet. 2007;369:1208–1219
  9. Pratt J. Too much aldosterone—more common than we ever realized?. Am J Hypertens. 2006;19:25–26
  10. Rodriguez E, Diaz M, Niembro E, Amato D, San-Juan E, Paniagua R. Effect of parathyroidectomy on cardiac fibrosis and apoptosis: possible role of aldosterone. Nephron Physiol. 2006;103:112–118
  11. Seifarth C, Trenkel S, Schobel H, Hahn E, Hensen J. Influence of antihypertensive medication on aldosterone and renin concentration in the differential diagnosis of essential hypertension and primary aldosteronism. Clin Endocrinol. 2002;57:457–465
  12. Barkan A, Marilus R, Winkelsberg G, Yeshurun D, Blum I. Primary hyperaldosteronism: possible cause of primary hyperaldosteronism in a 60-year-old woman. J Clin Endoc Metab. 1980;51:144–147
  13. Fallo F, Rocco S, Pagotto U, Zangari M, Luisetto G, Mantero F. Aldosterone and pressor responses to angiotensin II in primary hyperparathyroidism. J Hypertens. 1989;7:S192–S193
  14. Gennari C, Nami R, Gonnelli S. Hypertension and primary hyperparathyroidism: the role of adrenergic and renin-angiotensin-aldosterone systems. Miner Electrolyte Metab. 1995;21:77–81
  15. Jespersen B, Brock A, Charles P, Danielsen H, Sorensen S, Pedersen E. Unchanged noradrenaline reactivity and blood pressure after corrective surgery in primary hyperparathyroidism. Scand J Clin Lab Invest. 1993;53:479–486
  16. Kovacs L, Goth M, Szabolcs I, Dohan O, Ferencz A, Szilagyi G. The effect of surgical treatment on secondary hyperaldosteronism and relative hyperinsulinemia in primary hyperparathyroidism. Eur J Endocrinol. 1998;138:543–547
  17. Bernini G, Moretti A, Lonzi S, Bendinelli C, Miccoli P, Salvetti A. Renin-angiotensin-aldosteron system in primary hyperparathyroidism before and after surgery. Metabolism. 1999;48:298–300
  18. Ganguly A, Weinberger M, Passmore J, Caras J, Khairi R, Grim C, et al. The renin-angiotensin-aldosterone system and hypertension in primary hyperparathyroidism. Metabolism. 1982;31:595–600
  19. Jespersen B, Pedersen E, Charles P, Danielsen H, Juhl H. Elevated angiotensin II and vasopressin in primary hyperparathyroidism. Angiotensin II infusion studies before and after removal of the parathyroid adenoma. Acta Endocrinol. 1989;120:362–368
  20. Richards A, Espiner E, Nicholls M, Ikram H, Hamilton E, Maslowski A. Hormone, calcium and blood pressure relationships in primary hyperparathyroidism. J Hypertens. 1988;6:747–752
  21. Salahudeen A, Thomas T, Sellars L, Tapster S, Keavey P, Farndon JR, et al. Hypertension and renal dysfunction in primary hyperparathyroidism: effect of parathyroidectomy. Clin Sci. 1989;76:289–296
  22. El-Gharbawy A, Nadig V, Kotchen J, Grim C, Sagar K, Kaldunski M, et al. Arterial pressure, left ventricular mass, and aldosterone in essential hypertension. Hypertension. 2001;37:845–850
  23. Schlaich M, Schobel H, Hilgers K, Schmieder R. Impact of aldosterone on left ventricular structure and function in young normotensive and mildly hypertensive subjects. Am J Cardiol. 2000;85:1199–1206
  24. Grant F, Mandel S, Brown E, Williams G, Seely E. Interrelationships between the renin-angiotensin-aldosterone and calcium homeostatic systems. J Clin Endoc Metab. 1992;75:988–992
  25. Olgaard K, Lewin E, Bro S, Daugaard H, Egfjord M, Pless V. Enhancement of the stimulatory effect of calcium on aldosterone secretion by parathyroid hormone. Miner Electrolyte Metab. 1994;20:309–314

PII: S0039-6060(09)00693-X

doi: 10.1016/j.surg.2009.09.041

Surgery
Volume 146, Issue 6 , Pages 1035-1041 , December 2009

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