Surgery
Volume 148, Issue 1 , Pages 78-86 , July 2010

Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue

  • Aya Matsui, MD

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • Division of Cancer Diagnostics and Therapeutics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Eiichi Tanaka, MD, PhD

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • Division of Cancer Diagnostics and Therapeutics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    • ,
  • Hak Soo Choi, PhD

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • ,
  • Vida Kianzad, PhD

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • ,
  • Sylvain Gioux, PhD

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • ,
  • Stephen J. Lomnes, MS

      Affiliations

    • GE Healthcare, Princeton, NJ
    • ,
  • John V. Frangioni, MD, PhD

      Affiliations

    • Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
    • Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA
    • Corresponding Author InformationReprint requests: John V. Frangioni, MD, PhD, Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Room SL-B05, Boston, MA 02215.

,Accepted 7 December 2009.

References 

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  3. Visco AG, Taber KH, Weidner AC, Barber MD, Myers ER. Cost-effectiveness of universal cystoscopy to identify ureteral injury at hysterectomy. Obstet Gynecol. 2001;97:685–692
  4. Meirow D, Moriel EZ, Zilberman M, Farkas A. Evaluation and treatment of iatrogenic ureteral injuries during obstetric and gynecologic operations for nonmalignant conditions. J Am Coll Surg. 1994;178:144–148
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  6. Kim JH, Moore C, Jones JS, Rackley R, Daneshgari F, Goldman H, et al. Management of ureteral injuries associated with vaginal surgery for pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 2006;17:531–535
  7. Assimos DG, Patterson LC, Taylor CL. Changing incidence and etiology of iatrogenic ureteral injuries. J Urol. 1994;152:2240–2246
  8. Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. 2003;7:626–634
  9. Tanaka E, Ohnishi S, Laurence RG, Choi HS, Humblet V, Frangioni JV. Real-time intraoperative ureteral guidance using invisible near-infrared fluorescence. J Urol. 2007;178:2197–2202
  10. Frangioni JV, Kim SW, Ohnishi S, Kim S, Bawendi MG. Sentinel lymph node mapping with type-II quantum dots. Methods Mol Biol. 2007;374:147–159
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  12. Gioux S, Kianzad V, Ciocan R, Gupta S, Oketokoun R, Frangioni JV. High power, computer-controlled, LED-based light sources for fluorescence imaging and image-guided surgery. Mol Imaging. 2009;8:156–165
  13. Troyan SL, Kianzad V, Gibbs-Strauss SL, Gioux S, Matsui A, Oketokoun R, et al. The FLARE™ intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping. Ann Surg Oncol. 2009;16:2943–2952
  14. DiSanto AR, Wagner JG. Pharmacokinetics of highly ionized drugs. I. Methylene blue—whole blood, urine, and tissue assays. J Pharm Sci. 1972;61:598–602
  15. DiSanto AR, Wagner JG. Pharmacokinetics of highly ionized drugs. II. Methylene blue—absorption, metabolism, and excretion in man and dog after oral administration. J Pharm Sci. 1972;61:1086–1090
  16. Peter C, Hongwan D, Kupfer A, Lauterburg BH. Pharmacokinetics and organ distribution of intravenous and oral methylene blue. Eur J Clin Pharmacol. 2000;56:247–250
  17. Traynor S, Adams JR, Andersen P, Everts E, Cohen J. Appropriate timing and velocity of infusion for the selective staining of parathyroid glands by intravenous methylene blue. Am J Surg. 1998;176:15–17
  18. Bach KK, Lindsay FW, Berg LS, Howard RS. Prolonged postoperative disorientation after methylene blue infusion during parathyroidectomy. Anesth Analg. 2004;99:1573–1574
  19. Majithia A, Stearns MP. Methylene blue toxicity following infusion to localize parathyroid adenoma. J Laryngol Otol. 2006;120:138–140
  20. Khan MA, North AP, Chadwick DR. Prolonged postoperative altered mental status after methylene blue infusion during parathyroidectomy: a case report and review of the literature. Ann R Coll Surg Engl. 2007;89:W9–11
  21. Berland TL, Smith SL, Metzger PP, Nelson KL, Fakhre GP, Chua HK, et al. Intraoperative gamma probe localization of the ureters: a novel concept. J Am Coll Surg. 2007;205:608–611
  22. Mokhlesi B, Leikin JB, Murray P, Corbridge TC. Adult toxicology in critical care: part II: specific poisonings. Chest. 2003;123:897–922
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 Supported by National Institutes of Health (National Cancer Institute) Grant #R01-CA-115296 and a sponsored research agreement from GE Healthcare.

PII: S0039-6060(09)00794-6

doi: 10.1016/j.surg.2009.12.003

Surgery
Volume 148, Issue 1 , Pages 78-86 , July 2010

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