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Surgery
Volume 148, Issue 1
, Pages 110-118
, July 2010
Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model
References
- . Long-term results of percutaneous aspiration embolectomy. Cardiovasc Intervent Radiol. 1994;17:241–246
- . Management of acute leg ischaemia in the elderly. Br J Surg. 1998;85:217–220
- . Acute limb ischemia due to arterial embolism or thrombosis: influence of limb ischemia versus pre-existing cardiac disease on postoperative mortality rate. J Cardiovasc Surg. 1988;29:32–36
- . Neutrophil mediated remote organ injury after lower torso ischemia and reperfusion is selectin and complement dependent. J Trauma. 2000;48:32–38
- . Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol. 1987;253:H699–H703
- . S-nitroso-N-acetylcysteine protects skeletal muscle against reperfusion injury. Microsurgery. 1998;18:299–305
- . Role of heparin in reducing skeletal muscle infarction in ischemia-reperfusion. Microcirc Endothelium Lymphatics. 1989;5:259–276
- Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J Thorac Cardiovasc Surg. 2004;127:1262–1269
- . Local administration of the poly ADP-ribose polymerase (PARP) inhibitor, PJ34 during hindlimb ischemia modulates skeletal muscle reperfusion injury. J Surg Res. 2006;135:233–237
- Polyadenosine diphosphate-ribose polymerase inhibition modulates skeletal muscle injury following ischemia reperfusion. Arch Surg. 2005;140:344–352
- . Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion. J Am Coll Surg. 2006;203:44–53
- Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle. Microsurgery. 2004;24:324–331
- . Study of warm ischemia followed by reperfusion on a lower limb model in rats: effect of allopurinol and streptokinase. Clinics. 2005;60:213–220
- Controlled reperfusion using a simplified perfusion system preserves function after acute and persistent limb ischemia: a preliminary study. J Vasc Surg. 2005;42:690–694
- . A comparions of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators. N Engl J Med. 1998;339:1105–1111
- . The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002;54:375–429
- Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 1999;18:4446–4454
- Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int J Mol Med. 2001;7:255–260
- Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents. Crit Care Med. 2002;30:1071–1082
- Development of reproducible histologic injury severity scores: skeletal muscle reperfusion injury. Surgery. 2008;143:126–133
- A novel model of acute murine hind limb ischemia. Am J Physiol Heart Circ Physiol. 2007;292:830–837
- . A noninvasive murine model of hind limb ischemia-reperfusion injury. J Surg Res. 2004;116:55–63
- Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit Care Med. 2002;30:974–980
- Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation. Circ Res. 2002;90:100–106
- . Mortality following lower limb ischemia-reperfusion: a systemic inflammatory response?. World J Surg. 1996;20:961–967
- . Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction. World J Surg. 2002;26:115–121
- Enoxaparin does not ameliorate limb ischemia-reperfusion injury. J Surg Res. 2008;147:260–266
- CXC chemokine expression and synthesis in skeletal muscle during ischemia/reperfusion. J Vasc Surg. 2005;42:337–343
- . Inosine attenuates tourniquet induced skeletal muscle reperfusion injury. J Surg Res. 2001;99:311–315
- . Poly (ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006;55:3004–3012
- Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res. 2001;50:561–569
- . Prolonged adenine nucleotide resynthesis and reperfusion injury in postischemic skeletal muscle. Am J Physiol. 1992;262:H1538–H1547
- Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. Oncogene. 1999;18:4616–4625
- . PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells. Apoptosis. 2007;12:2037–2049
- Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest. 2003;112:1049–1057
- . Inflammatory responses to ischemia and reperfusion in skeletal muscle. Mol Cell Biochem. 1998;179:169–187
- Inhibition of interleukin-8 blocks myocardial ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 1998;116:114–121
- . Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res. 2001;89:684–691
- . PARP inhibitors: will the new class of drugs match the hype?. J Natl Cancer Inst. 2009;101:1230–1232
Supported by the Pacific Vascular Research Foundation, the American Diabetes Association, the Geneen Fund at the Massachusetts General Hospital, and Grant 1R01AR055843 from the National Institutes of Health.
PII: S0039-6060(09)00798-3
doi: 10.1016/j.surg.2009.12.006
© 2010 Mosby, Inc. All rights reserved.
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Surgery
Volume 148, Issue 1
, Pages 110-118
, July 2010
