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Surgery
Volume 148, Issue 1
, Pages 59-70
, July 2010
Transient perioperative pharmacologic inhibition of muscularis macrophages as a target for prophylaxis of postoperative ileus does not affect anastomotic healing in mice
References
- . Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus. Ann Surg. 1998;228:652–663
- Inhibition of macrophage function prevents intestinal inflammation and postoperative ileus in rodents. Gut. 2007;56:176–185
- Wound healing in the PU.1 null mouse–tissue repair is not dependent on inflammatory cells. Curr Biol. 2003;13:1122–1128
- . Understanding the role of immune regulation in wound healing. Am J Surg. 2004;187:11S–16
- . The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol. 1975;78:71–100
- . Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15:599–607
- . Healing of experimental intestinal anastomoses. Parameters for repair. Dis Colon Rectum. 1990;33:891–901
- . Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods. 1994;174:83–93
- . Basic experimental studies and clinical aspects of gadolinium salts and chelates. Cardiovasc Drug Rev. 2001;19:41–56
- . Op/op mice defective in production of functional colony-stimulating factor-1 lack macrophages in muscularis externa of the small intestine. Cell Tissue Res. 1999;295:485–493
- The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 1990;345:442–444
- . Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. Am J Physiol Gastrointest Liver Physiol. 2000;278:G259–G265
- Resident macrophages are involved in intestinal transplantation-associated inflammation and motoric dysfunction of the graft muscularis. Am J Transplant. 2007;7:1062–1070
- A semiquantitative histological analysis of repair of anastomoses in the rat colon after combined preoperative irradiation and local hyperthermia. Radiat Res. 1998;149:372–377
- . Microscopic analysis of anastomotic healing in the intestine of normal and diabetic rats. Dis Colon Rectum. 2001;44:423–431
- The effects of systemic hypoxia on colon anastomotic healing: an animal model. Dis Colon Rectum. 2005;48:1460–1470
- . Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J. 1979;11:447–455
- . Impact of pressure and gas type on anastomotic wound healing in rats. Langenbecks Arch Surg. 2004;389:261–266
- Changes of the extracellular matrix as a risk factor for anastomotic leakage after large bowel surgery. Surgery. 2005;137:229–234
- . Matrix metalloproteinases in wound repair (review). Int J Mol Med. 2000;6:391–407
- . Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology. 1999;117:378–387
- Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice. Gastroenterology. 2003;125:1137–1147
- Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology. 2004;126:159–169
- Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. Ann Surg. 2003;237:301–315
- Leukocyte-derived inducible nitric oxide synthase mediates murine postoperative ileus. Ann Surg. 2006;244:220–229
- . Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol. 2003;73:448–455
- . Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc Natl Acad Sci U S A. 2005;102:99–104
- . Effect of macrophage stimulation on collagen biosynthesis in the healing wound. Am Surg. 1997;63:125–131
- . The beneficial effect of enhanced macrophage function on the healing of bowel anastomoses. Am Surg. 1996;62:14–18
- . Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science. 1988;241:708–712
- . Collagen changes around intestinal anastomoses in germ-free rats. Br J Surg. 1989;76:797–801
- . Breaking strength of small intestinal anastomoses. Am J Surg. 1983;145:800–803
- Inhibition of p38 mitogen-activated protein kinase pathway as prophylaxis of postoperative ileus in mice. Gastroenterology. 2009;136:619–629
Supported by a grant from the Deutsche Forschungsgesellschaft (DFG) (KA1270/3-1/2) to the Clinical Research Group (KFO 115), and through a BONFOR Grant O-112.0028. Chlodronate was a generous gift of Roche Diagnostics GmbH, Mannheim, Germany.
PII: S0039-6060(09)00813-7
doi: 10.1016/j.surg.2009.12.010
© 2010 Mosby, Inc. All rights reserved.
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Surgery
Volume 148, Issue 1
, Pages 59-70
, July 2010
