Surgery
Volume 148, Issue 1 , Pages 71-77 , July 2010

The effects of intravenous nitroglycerine and norepinephrine on gastric microvascular perfusion in an experimental model of gastric tube reconstruction

  • Jasper Van Bommel, MD, PhD

      Affiliations

    • Department of Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands
    • Corresponding Author InformationReprint requests: Jasper Van Bommel, MD, PhD, Department of Intensive Care H-602, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    • ,
  • Jeroen De Jonge, MD, PhD

      Affiliations

    • Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Marc P. Buise, MD

      Affiliations

    • Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Anesthesiology, ICU, and Pain Therapy, Catharina Hospital, Eindhoven, The Netherlands
    • ,
  • Patricia Specht

      Affiliations

    • Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Michel Van Genderen

      Affiliations

    • Department of Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands
    • ,
  • Diederik Gommers, MD, PhD

      Affiliations

    • Department of Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands
    • Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands

,Accepted 15 December 2009.

References 

  1. Pierie JP, De Graaf PW, Poen H, Van der Tweel I, Obertop H. Impaired healing of cervical oesophagogastrostomies can be predicted by estimation of gastric serosal blood perfusion by laser Doppler flowmetry. Eur J Surg. 1994;160:599–603
  2. Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry. J Thorac Cardiovasc Surg. 2001;122:1101–1106
  3. Miyazaki T, Kuwano H, Kato H, Yoshikawa M, Ojima H, Tsukada K. Predictive value of blood flow in the gastric tube in anastomotic insufficiency after thoracic esophagectomy. World J Surg. 2002;26:1319–1323
  4. Tarui T, Murata A, Watanabe Y, Kim SP, Inoue M, Shiozaki H, et al. Earlier prediction of anastomotic insufficiency after thoracic esophagectomy by intramucosal pH. Crit Care Med. 1999;27:1824–1831
  5. Murakami M, Sugiyama A, Ikegami T, Ishida K, Maruta F, Shimizu F, et al. Revascularization using the short gastric vessels of the gastric tube after subtotal esophagectomy for intrathoracic esophageal carcinoma. J Am Coll Surg. 2000;190:71–77
  6. Kono K, Sugai H, Omata H, Fujii H. Transient bloodletting of the short gastric vein in the reconstructed gastric tube improves gastric microcirculation during esophagectomy. World J Surg. 2007;31:780–784
  7. Buise MP, Ince C, Tilanus HW, Klein J, Gommers D, van Bommel J. The effect of nitroglycerin on microvascular perfusion and oxygenation during gastric tube reconstruction. Anesth Analg. 2005;100:1107–1111
  8. Tobari S, Ikeda Y, Takami H. Beneficial effects of intravenous administration of lipo-prostaglandin E1 on the ischemic gastric tube in pigs. J Surg Res. 2005;129:79–84
  9. Matsuzaki Y, Edagawa M, Maeda M, Shimizu T, Sekiya R, Nakamura K, et al. Beneficial effect of prostaglandin E1 on blood flow to the gastric tube after esophagectomy. Ann Thorac Surg. 1999;67:908–910
  10. Lázár G, Kaszaki J, Abrahám S, Horváth G, Wolfárd A, Szentpáli K, et al. Thoracic epidural anesthesia improves the gastric microcirculation during experimental gastric tube formation. Surgery. 2003;134:799–805
  11. Michelet P, Roch A, D'Journo XB, Blayac D, Barrau K, Papazian L, et al. Effect of thoracic epidural analgesia on gastric blood flow after oesophagectomy. Acta Anaesthesiol Scand. 2007;51:587–594
  12. In:  Buise M,  van Bommel J,  Ince C editor. Reflectance spectrophotometry and tissue oxygenation in experimental and clinical practice. Yearbook of Intensive Care and Emergency Medicine 2003. Berlin: Heidelberg Springer Verlag; 2003;
  13. Schilling MK, Mettler D, Redaelli C, Büchler MW. Circulatory and anatomic differences among experimental gastric tubes as esophageal replacement. World J Surg. 1997;21:992–997
  14. Schröder W, Beckurts KT, Stähler D, Stützer H, Fischer JH, Hölscher AH. Microcirculatory changes associated with gastric tube formation in the pig. Eur Surg Res. 2002;34:411–417
  15. Theodorou D, Drimousis P, Larentzakis A, Papalois A, Toutouzas K, Katsaragakis S. The effects of vasopressors on perfusion of gastric graft after esophagectomy. An experimental study. J Gastrointest Surg. 2008;2:1497–1501
  16. Buise M, van Bommel J, Jahn A, Tran K, Tilanus H, Gommers D. Intravenous nitroglycerin does not preserve gastric microcirculation during gastric tube reconstruction: a randomized controlled trial. Crit Care. 2006;10:R131
  17. Pique JM, Whittle BJ, Esplugues JV. The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation. Eur J Pharmacol. 1989;174:293–296
  18. Iribe G, Ohnishi Y, Hayaschi Y, Kuro M. Effect of prostaglandin E1 and nitroglycerine on portal venous blood flow during hypothermic extracorporeal circulation: assessment by transesophageal echography. Acta Anaesthesiol Scand. 1999;43:520–525
  19. Spronk P, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerine in septic shock after intravascular volume resuscitation. Lancet. 2002;360:1395–1396
  20. Siegemund M, Van Bommel J, Sinaasappel M, Schwarte LA, Studer W, Girard T, et al. The NO donor SIN-1 improves intestinal-arterial P(CO(2)) gap in experimental endotoxemia: an animal study. Acta Anaesthesiol Scand. 2007;51:693–700
  21. Al-Rawi OY, Pennefather SH, Page RD, Dave I, Russell GN. The effect of thoracic epidural bupivacaine and an intravenous adrenaline infusion on gastric tube blood flow during esophagectomy. Anesth Analg. 2008;106:884–887
  22. LeDoux D, Astiz ME, Carpati CM, Rackow EC. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med. 2000;28:2729–2732
  23. Jacobi CA, Zieren HU, Muller JM, Adili F, Pichlmaier H. Anastomotic tissue oxygen tension during esophagectomy in patients with esophageal carcinoma. Eur Surg Res. 1996;28:26–31
  24. Jacobi CA, Zieren HU, Zieren J, Muller JM. Is tissue oxygen tension during esophagectomy a predictor of esophagogastric anastomotic healing?. J Surg Res. 1998;74:161–164
  25. Schröder W, Beckurts KT, Stähler D, Stützer H, Fischer JH, Hölscher AH. Microcirculatory changes associated with gastric tube formation in the pig. Eur Surg Res. 2002;34:411–417
  26. Temmesfeld-Woldbruck B, Szalay A, Mayer K, Olscheweski H, Seeger W, Grimminger F. Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine. Am J Resp Crit Care Med. 1998;157:1586–1592
  27. Siegemund M, van Bommel J, Ince C. Assessment of regional tissue oxygenation. Int Care Med. 1999;25:1044–1060
  28. Schröder W, Stippel D, Gutschow C, Leers J, Hölscher AH. Postoperative recovery of microcirculation after gastric tube formation. Langenbeck's Arch Surg. 2004;389:267–271

PII: S0039-6060(09)00814-9

doi: 10.1016/j.surg.2009.12.011

Surgery
Volume 148, Issue 1 , Pages 71-77 , July 2010

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