Surgery
Volume 148, Issue 3 , Pages 567-572 , September 2010

The antiendotoxin agent taurolidine potentially reduces ischemia/reperfusion injury through its metabolite taurine

  • Kishore K. Doddakula, Mch

      Affiliations

    • Department of Cardiac Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • ,
  • Peter M. Neary, MB

      Affiliations

    • Academic Department of Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • ,
  • Jiang H. Wang, PhD

      Affiliations

    • Academic Department of Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • ,
  • Shastri Sookhai, MD, FRCSI

      Affiliations

    • Academic Department of Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • ,
  • Aongus O'Donnell, MD, FRCSI(CTh)

      Affiliations

    • Department of Cardiac Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • ,
  • Tom Aherne, MB, FRCSI

      Affiliations

    • Department of Cardiac Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • ,
  • David J. Bouchier-Hayes, MD, FRCS

      Affiliations

    • Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    • ,
  • Henry P. Redmond, Mch, FRCSI

      Affiliations

    • Academic Department of Surgery, University College Cork, Cork University Hospital, Cork, Ireland
    • Corresponding Author InformationReprint requests: Henry P. Redmond, Mch, FRCSI, Department of Academic Surgery, Cork University Hospital, Wilton, Cork, Ireland.

,Accepted 14 January 2010.

References 

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  2. Steinberg JB, Kapelanski DP, Olson JD, Weiler JM. Cytokine and complement levels in patients undergoing cardiopulmonary bypass. J Thorac Cardiovascr Surg. 1993;106:1008–1016
  3. Deng MC, Dasch B, Erren M, Möllhoff T, Scheld HH. Impact of left ventricular dysfunction on cytokines, hemodynamics, and outcome in bypass grafting. Ann Thorac Surg. 1996;62:184–190
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  7. Holmberg SR, Cumming DV, Kusama Y, Hearse DJ, Poole-Wilson PA, Shattock MJ, et al. Reactive oxygen species modify the structure and function of the cardiac sarcoplasmic reticulum calcium-release channel. Cardioscience. 1991;2:19–21
  8. Hearse D, Tosaki A. Free radicals and calcium: simultaneous interacting triggers as determinants of vulnerability to reperfusion-induced arrhythmias in the rat heart. J Mol Cell Cardiol. 1988;20:213–223
  9. Bernier M, Hearse DJ, Manning AS. Reperfusion-induced arrhythmias and oxygen-derived free radicals. Studies with “anti-free radical” interventions and a free radical-generating system in the isolated perfused rat heart. Circ Res. 1986;58:331–340
  10. Raschke P, Massoudy P, Becker B. Taurine protects the heart from neutrophil-induced reperfusion injury. Free Radic Biol Med. 1995;19:461–471
  11. Milei J, Ferreira R, Llesuy S, Forcada P, Covarrubias J, Boveris A. Reduction of reperfusion injury with preoperative rapid intravenous infusion of taurine during myocardial revascularization. Am Heart J. 1992;123:339–345
  12. Sturman J. Taurine in development. Physiol Rev. 1993;73:119–147
  13. Myers E, Allwood M, Gidley M, Sanders J. The relationship between structure and activity of taurolin. J Appl Microbiol. 2008;48:89–96
  14. McCartney AC, Browne MK. Clinical studies on administration of taurolin in severe sepsis: a preliminary study. Prog Clin Biol Res. 1988;272:361–371
  15. Ryan T, Mc Carthy JF, Rady MY, Serkey J, Gordon S, Starr NJ, et al. Early bloodstream infection after cardiopulmonary bypass: frequency rate, risk factors, and implications. Crit Care Med. 1997;25:2009–2014
  16. Mauney M, Kron I. The physiologic basis of warm cardioplegia. Ann Thorac Surg. 1995;60:819–823
  17. Lichtenstein S, Ashe K, El Dalati H, Cusimano R, Panos A, Slutsky A. Warm heart surgery. J Thorac Cardiovasc Surg. 1991;101:269
  18. Hanna J, Chahine R, Aftimos G, Nader M, Mounayar A, Esseily F, et al. Protective effect of taurine against free radicals damage in the rat myocardium. Exp Toxicol Pathol. 2004;56:189–194
  19. Satoh H. Modulations by taurine of the spontaneous action potentials in right atrial muscles of rats. Gen Pharmacol. 1998;30:209–212

 Conflict of interest: The authors are currently engaged in an unrelated, sponsored clinical trial using taurolidine.

PII: S0039-6060(10)00022-X

doi: 10.1016/j.surg.2010.01.006

Surgery
Volume 148, Issue 3 , Pages 567-572 , September 2010

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