Surgery
Volume 148, Issue 4 , Pages 638-645 , October 2010

Pancreatic cyst aspiration analysis for cystic neoplasms: Mucin or carcinoembryonic antigen—Which is better?

  • Gareth Morris-Stiff, MD, PhD

      Affiliations

    • Department of Hepato-Pancreato-Biliary Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Greg Lentz

      Affiliations

    • Department of Hepato-Pancreato-Biliary Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Sricharan Chalikonda, MD

      Affiliations

    • Department of Hepato-Pancreato-Biliary Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Michael Johnson, MD

      Affiliations

    • Department of Hepato-Pancreato-Biliary Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Charles Biscotti, MD

      Affiliations

    • Department of Anatomic Pathology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • Tyler Stevens, MD

      Affiliations

    • Department of Gastroenterology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • ,
  • R. Matthew Walsh, MD

      Affiliations

    • Department of Hepato-Pancreato-Biliary Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH
    • Corresponding Author InformationReprint requests: R. Matthew Walsh, MD, Department of Hepato-Pancreato-Biliary Surgery, Cleveland Clinic Foundation, A10-100, 9500 Euclid Avenue, Cleveland, OH 44195.

References 

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  20. Maire F, Voitot H, Aubert A, et al. Intraductal papillary mucinous neoplasms of the pancreas: performance of pancreatic fluid analysis for positive diagnosis and the prediction of malignancy. Am J Gastroenterol. 2008;103:2871–2877
  21. Snozek CL, Mascarenhas RC, O'Kane DJ. Use of cyst fluid CEA, CA19-9, and amylase for evaluation of pancreatic lesions. Clin Biochem. 2009;42:1585–1588
  22. Walsh RM, Henderson JM, Vogt DP, et al. Prospective preoperative determination of mucinous pancreatic cyst neoplasms. Surgery. 2002;132:628–634
  23. Walsh RM, Zuccaro G, Dumot JA, et al. Predicting success of endoscopic aspiration for suspected pancreatic cystic neoplasms. JOP. 2008;9:612–617
  24. Deeks JJ, Altman DG. Diagnostic tests 4: likelihood ratios. BMJ. 2004;329:168–169
  25. Laucirica R, Schwartz MR, Ramzy I. Fine needle aspiration of pancreatic cystic epithelial neoplasms. Acta Cytol. 1992;36:881–886
  26. Lüttges J, Zamboni G, Longnecker D, Klöppel G. The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma. Am J Surg Pathol. 2001;25:942–948
  27. Lüttges J, Feyerabend B, Buchelt T, Pacena M, Klöppel G. The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas. Am J Surg Pathol. 2002;26:466–471
  28. Layfield LJ, Cramer H. Fine-needle aspiration cytology of intraductal papillary-mucinous tumors: a retrospective analysis. Diagn Cytopathol. 2005;32:16–20
  29. Lewandrowski KB, Southern JF, Pins MR, Compton CC, Warshaw AL. Cyst fluid analysis in the differential diagnosis of pancreatic cysts. A comparison of pseudocysts, serous cystadenomas, mucinous cystic neoplasms, and mucinous cystadenocarcinoma. Ann Surg. 1993;217:41–47
  30. Linder JD, Geenen JE, Catalano MF. Cyst fluid analysis obtained by EUS-guided FNA in the evaluation of discrete cystic neoplasms of the pancreas: a prospective single-center experience. Gastrointest Endosc. 2006;64:697–702

PII: S0039-6060(10)00391-0

doi: 10.1016/j.surg.2010.07.023

Surgery
Volume 148, Issue 4 , Pages 638-645 , October 2010

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