Surgery
Volume 148, Issue 4 , Pages 654-660 , October 2010

Expression of the Sonic Hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy

  • Kirbylee K. Nelson, BS

      Affiliations

    • Rush Medical College, Chicago, IL
    • ,
  • Paolo Gattuso, MD

      Affiliations

    • Department of Pathology, Rush University Medical Center, Chicago, IL
    • ,
  • Xiulong Xu, PhD

      Affiliations

    • Department of General Surgery, Rush University Medical Center, Chicago, IL
    • ,
  • Richard A. Prinz, MD

      Affiliations

    • Department of Surgery, NorthShore University HealthSystem, Evanston, IL
    • Corresponding Author InformationReprint requests: Richard A. Prinz, MD, Department of Surgery, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, IL 60201.

References 

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  2. Omenetti A, Dieh AM. The adventures of Sonic Hedgehog in development and repair. II. Sonic Hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol. 2008;294:G595–G598
  3. Bhardwaj G, Murdoch B, Wu D, Baker DP, Williams KP, Chadwick K, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2:172–180
  4. Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006;66:6063–6071
  5. Ahn S, Joyner AL. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature. 2005;437:894–897
  6. Hooper JE, Scott MP. Communicating with Hedgehogs. Nat Rev Mol Cell Biol. 2005;6:306–317
  7. Dormoy V, Danilin S, Lindner V, Thomas L, Rothhut S, Coquard C, et al. The sonic hedgehog signaling pathway is activated in human renal cell carcinoma and plays orchestral role in tumor growth. Mol Cancer. 2009;8:123
  8. Parkin CA, Ingham PW. The adventures of Sonic Hedgehog in development and repair. I. Hedgehog signaling in gastrointestinal development and disease. Am J Physiol Gastrointest Liver Physiol. 2008;294:G363–G367
  9. Zheng X, Mann RK, Sever N, Beachy PA. Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010;24:57–71
  10. Fagman H, Grande M, Gritli-Linde A, Nilsson M. Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse. Am J Pathol. 2004;164:1865–1872
  11. Greco A, Borrello MG, Miranda C, Degl'Innocenti D, Pierotti MA. Molecular pathology of differentiated thyroid cancer. Q J Nucl Med Mol Imaging. 2009;53:440–454
  12. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 2003;63:1454–1457
  13. Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer. 2005;12:245–262
  14. Asai J, Takenaka H, Kusano KF, Ii M, Luedemann C, Curry C, et al. Topical Sonic Hedgehog gene therapy accelerates wound healing in diabetics by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation. 2006;113:2413–2424
  15. Yang L, Xie G, Fan Q, Xie J. Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene. 2010;29:469–481
  16. Jang KT, Lee KT, Lee JG, Choi SH, Heo JS, Choi DW, et al. Immunohistochemical expression of sonic hedgehog in intraductal papillary mucinous tumor of the pancreas. Appl Immunohistochem Mol Morphol. 2007;15:294–298
  17. Xuan YH, Li GL, Jiang HY, Lin ZH. Relationship between hedgehog signaling pathway molecules and HPV16 infection in uterine cervical cancers. Zhonghua Bing Li Xue Za Zhi. 2009;38:178–182
  18. Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst. 2010;6:44–54
  19. Hirotsu M, Setoguchi T, Sasaki H, Matsunoshita Y, Gao H, Nagao H, et al. Smoothened as a new therapeutic for human osteosarcoma. Mol Cancer. 2010;12:5
  20. Mao L, Xia YP, Zhou YN, Dai RL, Yang X, Yang YJ, et al. Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma. Oncology. 2009;77:231–243
  21. Kawahara T, Kawaguchi-Ihara N, Okuhashi Y, Itoh M, Nara N, Tohda S. Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res. 2009;29:4629–4632

PII: S0039-6060(10)00398-3

doi: 10.1016/j.surg.2010.07.030

Surgery
Volume 148, Issue 4 , Pages 654-660 , October 2010

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