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Abstract
Determinations of the plasma volume, “available (thiocyanate) volume,” total plasma
protein and plasma albumin concentrations, and hematocrit were carried out in normal
and hypoproteinemic dogs before and following a single nonfatal hemorrhage (25 per
cent of the measured blood volume). No nitrogen or fluid replacement was instituted
for a period of 24 hours after the hemorrhage. The pertinent findings may be briefly
summarized as follows:
- 1.1. Following a single nonfatal hemorrhage in normal dogs there was found to be a prompt, but gradual, restoration of the plasma volume and of the total amount of circulating plasma proteins. After the animals had resumed a normal diet for several days the average levels for the plasma volume and the total circulating plasma proteins were found to exceed the average control values.
- 2.2. In normal dogs the initial increase in plasma volume was found to be due to the addition of fluid relatively low in protein. During a 4-hour interval, the plasma was found to have regained, on the average, 60 per cent of the volume, 24 per cent of the total protein, and 26 per cent of the albumin lost by the hemorrhage.
- 3.3. The initial increase of plasma volume following hemorrhage was found to be associated with a fall of the “available (thiocyanate) volume.” The direction of these changes, when no fluid replacement was instituted, was taken to indicate that the fluid entering the plasma was derived chiefly from the interstitial spaces.
- 4.4. The plasma volume was found to increase promptly following a single nonfatal hemorrhage in hypoproteinemic dogs. Observations which were made 4 hours and 24 hours after the hemorrhage indicated that some protein had been added to the plasma. Even though the average plasma volume returned to the control level, after the animals had resumed a low protein diet for several days, plasma protein restoration was incomplete.
- 5.5. Despite the fact that the animals were in a state of protein depletion, the plasma regained during a 4-hour period, on the average, 60 per cent of the volume, 21 per cent of the total protein, and 37 per cent of the albumin lost by the hemorrhage. The source of this protein was not apparent.
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References
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Pride, M. P., Griffin, G. E., Muntwyler, E., Mautz, F. R., and Kuether, C. A.: Plasma Albumin Regeneration in the Dog With Nutritional Hypoproteinemia Following Oral Administration of Dried Beef Serum. (Unpublished Data.)
Article info
Publication history
Received:
February 5,
1945
Footnotes
☆Aided by a grant from the John and Mary R. Markle Foundation.
Identification
Copyright
© 1945 Published by Elsevier Inc.
