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Evidence is presented in support of some of the factors which appear to be involved in the pathogenesis of caffeine-induced ulcers. It is believed that the proteolytic action of acid and pepsin secretion upon a gastric mucosa, rendered more susceptible to the ulcerative process by the vascular and “cellular” changes induced by caffeine, results in the development of an ulcer.
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Received: September 5, 1944
© 1945 Published by Elsevier Inc.