Original communication| Volume 32, ISSUE 6, P980-987, December 1952

Sulfadimbtine, a new sulfonamide for the treatment of urinary infections

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      • 1.
        1. Sulfadimetine is effective against a variety of gram-negative and gram-positive bacteria commonly encountered in urinary infections. In many instances the drug possesses a greater antibacterial effect in vitro than other sulfonamides. It is often effective when antibiotics fail.
      • 2.
        2. Sulfadimetine shows a low order of acetylation (about 10 per cent), and blood levels of 6 to 8 mg. per cent of free sulfonamide are easily maintained on 4 Gm. daily.
      • 3.
        3. Clinical trial in 40 patients with urinary infections yielded a satisfactory response in 27. Improvement was observed in some patients with polyvalent as well as with monovalent infections.
      • 4.
        4. There were no untoward reactions. With no attempt made to maintain an adequate daily fluid intake or to alkalinize the urine, no renal or hematopoietic toxicity occurred.
      • 5.
        5. Apart from the notable lack of toxicity and the low order of acetylation, which recommend its use, sulfadimetine frequently proves more effective than other sulfonamides and antibiotics.
      • 6.
        6. The in vitro sensitivity test is a reliable guide to the clinical antibacterial effectiveness of this drug.
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      1. Rutenburg, A. M.: To be published.

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