Sulfadimbtine, a new sulfonamide for the treatment of urinary infections

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Abstract

1.
1. Sulfadimetine is effective against a variety of gram-negative and gram-positive bacteria commonly encountered in urinary infections. In many instances the drug possesses a greater antibacterial effect in vitro than other sulfonamides. It is often effective when antibiotics fail.
2.
2. Sulfadimetine shows a low order of acetylation (about 10 per cent), and blood levels of 6 to 8 mg. per cent of free sulfonamide are easily maintained on 4 Gm. daily.
3.
3. Clinical trial in 40 patients with urinary infections yielded a satisfactory response in 27. Improvement was observed in some patients with polyvalent as well as with monovalent infections.
4.
4. There were no untoward reactions. With no attempt made to maintain an adequate daily fluid intake or to alkalinize the urine, no renal or hematopoietic toxicity occurred.
5.
5. Apart from the notable lack of toxicity and the low order of acetylation, which recommend its use, sulfadimetine frequently proves more effective than other sulfonamides and antibiotics.
6.
6. The in vitro sensitivity test is a reliable guide to the clinical antibacterial effectiveness of this drug.

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Received: February 25, 1952

☆Aided by a grant from Ciba Pharmaceutical Products, Inc., Summit, N. J.

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