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Fresh and frozen aortic homografts were implanted in twenty-one dogs. Ten received cortisone and eleven were used as controls.
The cortisone-treated animals had an increased mortality rate. They showed less connective tissue reaction, both grossly and microscopically. There was subjective evidence of decreased healing. Cortisone had no effect on the frequency or extent of thrombosis in the grafts. Re-endothelialization was apparently normal in rate. Condensation of the elastic fibers and degeneration and phagocytosis of the graft muscle cells were reduced.
The results were not statistically significant.
We conclude that cortisone, under the conditions of this experiment, exerts little if any beneficial effect on aortic homografts. Some undesirable side effects were seen.
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Received: July 9, 1952
© 1953 Published by Elsevier Inc.