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Stimulation experiments in the monkey reveal dual hypothalamic influences increasing the secretion of gastric hydrochloric acid.
The first originates in the anterior hypothalamus, is conducted through the vagus nerve, and is blocked only by vagotomy. The peak of its response is prompt.
The second, whose peak response is later, arises in the posterior hypothalamus, is conducted humorally through the pituitary-adrenal system, and is blocked only by adrenalectomy.
The increase in gastric hydrochloric acid induced by administration of insulin, exhibits features of the responses to both anterior and posterior hypothalamic stimulation.
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Received: July 8, 1952
☆Aided by a grant from the National Institutes of Health, United States Public Health Service.
© 1953 Published by Elsevier Inc.