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Abstract
Within three to four weeks after superficial femoral artery ligation in the cat there
is a considerable increase in the size of the largest collateral vessel present. Lumbar
sympathectomy comparable to that usually performed in man for peripheral arterial
disease does not augment this increase in size within seventy-five days, the longest
any animal was studied.
Lumbar sympathectomy does dilate the arterial vessels of the feet, at least early
in arteriosclerosis obliterans. The eventual loss of the limb, however, is probably
determined by the state of the main artery and its collaterals rather than by the
existing degree of dilatation of the vessels of the feet.
In spite of this evidence in the cat it may be that lumbar sympathectomy as now performed
or a sympathectomy that also denervates the upper thigh vessels and the bifurcation
of the abdominal aorta might affect the collateral vessels favorably and so prolong
the life of the limb in progressive occlusive arterial disease in man. The need for
controlled studies on this point is long overdue.
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Article info
Publication history
Received:
September 10,
1954
Footnotes
☆This investigation was supported in part by a research grant, H-54, from the Cardiovascular Section of the National Instiutes of Health, Public Health Service, and in part by the Los Angeles Heart Association.
Identification
Copyright
© 1955 Published by Elsevier Inc.
