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Within three to four weeks after superficial femoral artery ligation in the cat there is a considerable increase in the size of the largest collateral vessel present. Lumbar sympathectomy comparable to that usually performed in man for peripheral arterial disease does not augment this increase in size within seventy-five days, the longest any animal was studied.
Lumbar sympathectomy does dilate the arterial vessels of the feet, at least early in arteriosclerosis obliterans. The eventual loss of the limb, however, is probably determined by the state of the main artery and its collaterals rather than by the existing degree of dilatation of the vessels of the feet.
In spite of this evidence in the cat it may be that lumbar sympathectomy as now performed or a sympathectomy that also denervates the upper thigh vessels and the bifurcation of the abdominal aorta might affect the collateral vessels favorably and so prolong the life of the limb in progressive occlusive arterial disease in man. The need for controlled studies on this point is long overdue.
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Received: September 10, 1954
☆This investigation was supported in part by a research grant, H-54, from the Cardiovascular Section of the National Instiutes of Health, Public Health Service, and in part by the Los Angeles Heart Association.
© 1955 Published by Elsevier Inc.