Original communication Society for Vascular Surgery| Volume 37, ISSUE 1, P64-79, January 1955

Some long-term observations on aortic homografts

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      Eighteen aortic homografts implanted into the abdominal aorta of dogs have been studied from eighteen months to four and one-half years after implantation. Function was excellent in all, and no aneurysms were noted. However, calcification and marked thinning were observed grossly. Microscopic examination revealed condensation of the graft with complete loss of cellular elements, and a thinning of the internal and external layers which developed from the fibroblasts of the recipient animal. Most significant was the marked degeneration of the elastic fibers of the homograft. The consistency of these changes, despite method of preservation of the graft, indicated that they are characteristic of aortic homografts per se. The marked degree of such alteration in some of these long-term grafts raised a question as to whether aneurysm might not ultimately have formed.
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