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Original communication Society for Vascular Surgery (concluded)| Volume 41, ISSUE 2, P198-210, February 1957

Changes in coagulation occurring in dogs during hypothermia and cardiac surgery

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      Abstract

      • 1.
        1. Coagulation changes have been studied in dogs undergoing hypothermia and cardiac surgery.
      • 2.
        2. A depletion of proaccelerin, proconvertin, prothrombin, and fibrinogen was found to occur. We believe that this results from intravascular clotting.
      • 3.
        3. Intravascular clotting predisposed to the dangers of thromboembolic phenomenon. Several deaths occurred with hypothermia and cardiac surgery which are believed to be attributable to pulmonary emboli.
      • 4.
        4. Furthermore, intravascular clotting depleted the blood of certain factors necessary for coagulation resulting in a clotting defect. Hemorrhage after rewarming was a significant problem in those animals undergoing hypothermia and cardiac surgery.
      • 5.
        5. Heparin was given intravenously to inhibit intravascular clotting. The depletion of coagulation factors was minimized. None of these animals showed evidence of thromboembolic phenomenon and the mortality was greatly reduced Furthermore, no post-rewarming hemorrhage occurred.
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