Original communication| Volume 46, ISSUE 3, P486-495, September 1959

Totally denervated pouches of gastric mucosa

Method and preliminary observations
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      • 1.
        1. A method is described for preparing pouches containing gastric mucosa which is believed to be completely devoid of any extrinsic or intrinsic innervation. The technique entails the transplantation of split-thickness grafts of gastric mucosa containing only epithelial elements and lamina propria.
      • 2.
        2. Grafts transplanted by this method from either the antrum or corpus of the stomach can survive and regenerate to essentially normal-appearing mucosa on microscopic sections.
      • 3.
        3. Preliminary observations indicate that transplanted totally denervated mucosa from the body of the stomach is able to secrete free hydrochloric acid in response to appropriate stimuli, whereas transplanted, totally denervated mucosa from the gastric antrum does not secrete gastrin in response to a normally potent natural stimulus (meat extract).
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