Original communication| Volume 46, ISSUE 3, P543-555, September 1959

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Observations of the cardiovascular system in experimental traumatic shock

I. General hemodynamics
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      Comprehensive studies of the respiratory and circulatory response of goats to standard experimental wounds were carried out in 8 control, 8 injured but untreated, and 8 injured, penicillin-treated animals.
      The animals were all evaluated in a restrained position on carts. A respiratory alkalosis was present, in all three groups.
      The injured animals developed a typical shocklike response after injury, with reduction in arterial pressure, cardiac output, and stroke volume. None of the factors observed, except that of the rate of decrease of circulating blood volume, could be correlated with the survival time. The penicillin-treated animals had a mean survival time of 29.7 hours, the untreated animals a mean of 19.7 hours.
      It was concluded that blood loss and infection of the wound with pathogenic clostridia act to produce similar over-all results physiologically. Distinction between the two, when both are active, is not possible by the methods used in these experiments.
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