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Original communication| Volume 46, ISSUE 3, P543-555, September 1959

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Observations of the cardiovascular system in experimental traumatic shock

I. General hemodynamics
DOI:https://doi.org/10.5555/uri:pii:0039606059901187
Observations of the cardiovascular system in experimental traumatic shock
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      Abstract

      Comprehensive studies of the respiratory and circulatory response of goats to standard experimental wounds were carried out in 8 control, 8 injured but untreated, and 8 injured, penicillin-treated animals.
      The animals were all evaluated in a restrained position on carts. A respiratory alkalosis was present, in all three groups.
      The injured animals developed a typical shocklike response after injury, with reduction in arterial pressure, cardiac output, and stroke volume. None of the factors observed, except that of the rate of decrease of circulating blood volume, could be correlated with the survival time. The penicillin-treated animals had a mean survival time of 29.7 hours, the untreated animals a mean of 19.7 hours.
      It was concluded that blood loss and infection of the wound with pathogenic clostridia act to produce similar over-all results physiologically. Distinction between the two, when both are active, is not possible by the methods used in these experiments.
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      References

        • Anderson R.S.
        • Rogers E.B.
        Hematocrit and Erythrocyte Volume Determinations in the Goat as Related to Spleen Behavior.
        Am. J. Physiol. 1957; 188: 178
        • Bald F.W.
        The Regulation of Respiration. VIII. The pH of the Arterial Blood and Respiration Volume as Affected by Blood Volume Changes.
        Am. J. Physiol. 1927; 81: 222
        • Blalock A.
        Experimental Shock. The Cause of the Low Blood Pressure Produced by Muscle Injury.
        Arch. Surg. 1930; 20: 959
        • Brannon E.S.
        • Stead E.A.
        • Warren J.V.
        • Merrill A.J.
        Hemodynamics of Acute Hemorrhage in Man.
        Am. Heart J. 1946; 31: 407
        • Burdette W.J.
        Oxygen Consumption of Cardiac Muscle During Shock.
        Am. J. Physiol. 1952; 168: 575
        • Burnett C.H.
        • Bland E.F.
        • Beecher H.K.
        Electrocardiograms in Traumatic Shock in Man.
        J. Clin. Invest. 1945; 24: 687
        • Corday E.
        • Bergman H.C.
        • Schwartz L.L.
        • Spritzler R.J.
        • Prinzmetal M.
        Studies on the Coronary Circulation. IV. The Effect of Shock on the Heart and Its Treatment.
        Am. Heart J. 1949; 37: 560
        • Cournand A.
        • Rile R.L.
        • Bradley S.E.
        • Bried E.S.
        • Noble B.P.
        • Iauson H.D.
        • Gregerson M.I.
        • Richards D.W.
        Studies of the Circulation in Clinical Shock.
        Surgery. 1943; 13: 964
        • Dill D.B.
        • Edwards H.T.
        • Consolazio W.V.
        Blood as a Physiochemical System. XI. Man at Rest.
        J. Biol. Chem. 1937; 118: 635
        • Dobson E.L.
        • Warner G.F.
        Factors Concerned in the Early Stages of Thermal Shock.
        Circulation Res. 1957; 5: 69
        • Edwards W.S.
        • Siegel A.
        • Bing R.J.
        Studies on Myocardial Metabolism. III. Coronary Blood Flow, Myocardial Oxygen Consumption and Carbohydrate Metabolism in Experimental Hemorrhagic Shock.
        J. Clin. Invest. 1954; 32: 1646
        • Evans E.I.
        • Hoover M.J.
        • James G.W.
        • Alm T.
        Studies on Traumatic Shock. I. Blood Volume Changes in Traumatic Shock.
        Ann. Surg. 1944; 119: 64
        • Fine J.
        • Seligman A.M.
        Traumatic Shock. VII. A Study of the Problem of the Lost Plasma in Hemorrhagic Tourniquet and Burn Shock by the Use of Radioactive lodoplasma Protein.
        J. Clin. Invest. 1944; 23: 720
        • Friedman J.J.
        Alterations in Tissue Plasma Volume With Nembutal Anesthesia.
        Am. J. Physiol. 1957; 189: 246
        • Fuhrman F.A.
        • Fuhrman G.J.
        • Field J.
        Oxygen Consumption of Excised Rat Tissue Following Acute Anoxic Anoxia.
        Am. J. Physiol. 1945; 144: 87
        • Gesell R.
        Studies on the Submaxillary Gland: A Comparison of the Effects of Hemorrhage and of Tissue-Abuse in Relation to Secondary Shock.
        Am. J. Physiol. 1918; 47: 468
        • Hackel D.B.
        • Goodale W.T.
        Effects of Hemorrhagic Shock on the Heart and Circulation of Intact Dogs.
        Circulation. 1955; 11: 628
        • Kendall M.G.
        The Advanced Theory of Statistics. Vol. II. Charles Griffin and Co., Ltd, London1943
        • Klement A.W.
        • Ayer D.E.
        • McIntyre D.R.
        Simultaneous Use of I131-Albumin and Cr51-Labelled Red Cell in Blood Volume Studies in the Goat.
        in: Proc. Soc. Exper. Biol. & Med. 87. 1954: 81
        • Kohlstaedt K.G.
        • Page I.H.
        Terminal Hemorrhagic Shock. Circulatory Dynamics, Recognition, and Treatment.
        Surgery. 1944; 16: 430
        • Kondo B.
        • Katz L.N.
        Heart Size in Shock Produced by Venous Occlusion of the Hind Limbs of the Dog.
        Am. J. Physiol. 1945; 143: 77
        • Lindsey D.
        • Wise H.M.
        • Knecht A.T.
        • Noyes H.E.
        The Role of Clostridia in Mortality Following an Experimental Wound in the Goat. I. Quantitative Bacteriology.
        Surgery. 1959; 45: 602
        • Mansberger A.R.
        • Ochsner E.W.
        • Jacob S.W.
        • Oppenheimer J.H.
        • Gillette R.W.
        A New Preparation for the Study of Experimental Shock From Massive Wounds. II. Evaluation of Various Therapeutic Regimens With Special Reference to the Role of Antibiotics, Fluid Replacement, and Débridement.
        Surgery. 1958; 43: 708
        • Melcher G.W.
        • Walcott W.W.
        Myocardial Changes Following Shock.
        Am. J. Physiol. 1951; 164: 832
        • Noble R.P.
        • Gregerson M.I.
        Blood Volume in Clinical Shock. II. The Extent and Cause of Blood Volume Reduction in Traumatic., Hemorrhagic, and Burn Shock.
        J. Clin. Invest. 1946; 25: 172
        • Oakley C.L.
        The Toxins of Clostridium Welchii.
        Bull. Hyg. 1943; 18: 781
        • O'Brien W.A.
        • Howie D.L.
        • Crosby W.H.
        Blood Volume Studies in Wounded Animals.
        Walter Reed Army Inst. Res. April, 1957; : 55-57
        • Ochsner E.W.
        • Jacob S.W.
        • Mansberger A.R.
        A New Preparation for the Study of Experimental Shock From Massive Wounds. I. Standardization.
        Surgery. 1958; 43: 703
        • Oppenheimer J.H.
        • Knecht A.T.
        • Mansberger A.R.
        • Gillette R.W.
        • Pon D.S.
        A New Preparation for the Study of Experimental Shock From Massive Wounds. IV. The Effect of Penicillin and Streptomycin on the Quantitative Bacteriological Flora of the Wound.
        Surgery. 1958; 43: 730
        • Prentice T.C.
        • Olney J.M.
        • Artz C.P.
        • Howard J.M.
        Studies of Blood Volume and Transfusion Therapy in the Korean Battle Casualty.
        Surg. Gynec. & Obst. 1954; 99: 542
        • Price P.B.
        • Hanlon C.R.
        • Longmire W.P.
        • Metcalf W.
        Experimental Shock. I. Effect of Acute Hemorrhage in Healthy Dogs.
        Bull. Johns Hopkins Hosp. 1941; 69: 327
        • Ravin H.A.
        • Denson J.R.
        • Jensen H.
        Electrolyte Shifts and Electrocardiographic Changes During Tourniquet Shock in Rats.
        Am. J. Physiol. 1954; 178: 419
        • Sarnoff S.J.
        • Case R.B.
        • Waithe P.E.
        • Isaacs J.P.
        Insufficient Coronary Flow and Myocardial Failure as a Complicating Factor in Late Hemorrhagic Shock.
        Am. J. Physiol. 1954; 176: 439
        • Schopp R.T.
        • Gilfoil T.M.
        • Youmans W.B.
        Mechanisms of Rrespiratory Stimulation During Hemorrhage.
        Am. J. Physiol. 1957; 189: 117
        • Strawitz J.G.
        • Huft H.
        A Study of Mitochondrial Changes in Hemorrhagic Shock.
        in: S. Forum. 7. 1957: 11
        • Van Noate H.F.
        Right and Left Atrial Pressures in Successive Stages of Oligemic and Normovolemic Shock.
        in: Proc. Soc. Exper. Biol. & Med. 76. 1951: 155
        • Wiggers C.J.
        Myocardial Depression in Shock. A Study of Cardiovascular Dynamics.
        Am. Heart J. 1947; 33: 633
        • Zweifach B.W.
        • Chambers R.
        • Lee R.E.
        • Hyman C.
        Reactions of Peripheral Blood Vessels in Experimental Hemorrhage.
        Ann. New York Acad. Sc. 1947–1948; 49: 553

      Article info

      Publication history

      Received: December 8, 1958

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606059901187

      Copyright

      © 1959 Published by Elsevier Inc.

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