Original communication| Volume 48, ISSUE 5, P894-902, November 1960

Download started.


Evaluation of endarterectomy in the presence of experimental hypercholesterolemia and atherosclerosis

      This paper is only available as a PDF. To read, Please Download here.


      Endarterectomy has been performed in the femoral arteries of a group of animals with experimental hypercholesterolemia and atherosclerosis. Nine of 14 vessels studied in this manner were found ultimately to remain patent. Occluding thrombosis occurred in five. Arteriography demonstrated some degree of luminal narrowing at the site of endarterectomy in all arteries which remained patent and the extent could be correlated with the degree of atherosclerosis observed at the time of operation. The findings indicate that small atherosclerotic arteries often remain patent after experimental endarterectomy, although reduction in the size of the lumen and development of thrombosis are significantly greater in this group than in control animals without atherosclerosis.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Barker W.F.
        Distal Operative Angiography as an Aid in Endarterectomy.
        Surgery. 1954; 36: 233
        • Cannon J.A.
        • Barker W.F.
        Successful Management of Obstructive Femoral Arteriosclerosis by Endarterectomy.
        Surgery. 1955; 38: 48
        • Cate Jr., W.R.
        • Scott Jr., H.W.
        Cerebral Ischemia of Central Origin: Relief by Subclavian-Vertebral Artery Thromboendarterectomy.
        Surgery. 1959; 45: 19
        • Creech Jr., O.
        • Jordan Jr., G.L.
        • De Bakey M.E.
        The Effect of Chronic Hypercholesterolemia on Synthetic Aortic Substitutes.
        Surg. Gynec. & Obst. 1957; 104: 385
        • Creech Jr., O.
        • Jordan Jr., G.L.
        • De Bakey M.E.
        • Overton R.C.
        • Halpert B.
        The Effect of Chronic Hypercholesterolemia on Canine Aortic Transplants.
        Surg. Gynec. & Obst. 1955; 101: 607
        • De Bakey M.E.
        • Crawford E.S.
        • Cooley D.A.
        • Morris Jr., G.C.
        Surgical Considerations of Occlusive Disease of the Abdominal Aorta and Iliac and Femoral Arteries: Analysis of 803 Cases.
        Ann. Surg. 1958; 148: 306
        • De Bakey M.E.
        • Crawford E.S.
        • Cooley D.A.
        • Morris Jr., G.C.
        Surgical Considerations of Occlusive Disease of Innominate, Carotid, Subclavian, and Vertebral Arteries.
        Ann. Surg. 1959; 149: 690
        • Gryska P.F.
        The Development of Atheroma in Arteries Subjected to Experimental Thromboendarterectomy.
        Surgery. 1959; 45: 655
        • Longmire W.P.
        • Cannon J.A.
        • Kattus A.A.
        Direct-Vision Coronary Endarterectomy for Angina Pectoris.
        New England J. Med. 1958; 259: 993
        • Sabiston D.C.
        Coronary Endarterectomy.
        Am. Surgeon. 1960; 26: 217
        • Sabiston D.C.
        • Fauteux J.P.
        • Blalock A.
        An Experimental Study of the Fate of Arterial Implants in the Left Ventricular Myocardium, With a Comparison of Similar Implants in Other Organs.
        Ann. Surg. 1957; 145: 6
        • Sabiston D.C.
        • Smith G.W.
        • Talbert J.L.
        Evaluation of Experimental Endarterectomy in Vessels of Different Caliber.
        Surg. Gynec. & Obst. 1960; 110: 563
        • Shaw R.S.
        • Maynard E.P.
        Acute and Chronic Thrombosis of the Mesenteric Arteries Associated With Malabsorption.
        New England J. Med. 1958; 258: 874
        • Steiner A.
        • Kendall F.E.
        • Bevans M.
        Production of Arteriosclerosis in Dogs by Cholesterol and Thiouracil Feeding.
        Am. Heart J. 1949; 38: 34