This paper is only available as a PDF. To read, Please Download here.
Clinical and epidemiologic studies raise the question of whether there might be a positive correlation between the incidence of goiter and the incidence of breast cancer. It appears that areas plagued with goiter tend to have a high breast cancer mortality rate. Conversely, areas with a low incidence of goiter seem to have a low breast cancer fatality rate. While such evidence is far from conclusive, it may be justifiable to regard the data as provocative and meriting further inquiry.
From the experimental laboratory there is evidence that impairment of thyroid function may affect the mammary gland to a considerable degree. This effect upon the breast appears to be mediated through the ovary secondary to pituitary activity which has been initiated by the thyroid dysfunction.
The possibility exists that goiter may indicate an endocrine abnormality of significance in human breast cancer. It appears to us that continued intensive study of the hormonal aspects of breast cancer is in order and also that a study of the phylogenetic relationship of hormone development to neoplasia might be warranted.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- On the treatment of inoperable cases of carcinoma of the mamma: suggestions for new methods of treatment with illustrative cases.Lancet. 1896; 2: 104-107
- On the treatment of inoperable cases of carcinoma of the mamma: suggestions for new methods of treatment with illustrative cases.Lancet. 1896; 2: 162-165
- Nature of the hormonal influence in mouse mammary cancer.Science. 1960; 125: 1039
Cancer mortality in the United States. III. Geographic variation in recorded cancer mortality for detailed sites, for an average of the years 1930–1932, Public Health Bulletin No. 257.
- Techniques in geographic pathology of cance.Schweiz. Ztschr. allg. Path. 1955; 18: 479
- Breast cancer and thyroid disease.Quart. Rev. Obst. & Gynec. 1960; 17: 139-147
- Experimental pituitary tumors and the role of pituitary hormones in tumorigenesis of the breast and thyroid.Cancer. 1957; 10: 842-853
- Comparative anatomy and physiology of anterior pituitary.Quart. Rev. Biol. 1941; 16: 294-310
- Diseases of thyroid gland.Grune & Stratton, Inc, New York1951
- Relationship of hormones and mammary adenocarcinoma in the mouse.Am. J. Cancer. 1939; 37: 414-424
- Hypophysis-thyroid-gonad relationship.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 34. 1936: 599-600
- The role of thyroid function and food intake in experimental ovarian tumorigenesis in mice.Cancer Res. 1954; 14: 220
- Effect of prolonged ingestion of thiourea on mammary glands and the appearance of mammary tumors in adult C3H mice.J. Nat. Cancer Inst. 1946; 7: 159-169
- The mechanism of hormonal carcinogenesis.in: Ciba Foundation Symposium. Little, Brown & Company, Boston1959: 83-94
- Distribution of endemic goiter in the United States as shown by thyroid surveys.Pub. Health Rep. 1926; 41: 2691-2703
- Distribution of endemic goiter in the United States as shown by thyroid surveys.Pub. Health Rep. 1929; 44: 1463-1487
- A cancer detection survey of carcinoma of the lung and female pelvis among Navajos on the Navajo Indian Reservation.Surg. Gynec. & Obst. 1959; 108: 257-266
- Geographical and racial distribution of cancer of the breast.Schweiz. Ztschr. allg. Path. 1955; 18: 668
- Urinary estrogen and related compounds in postmenopausal women with mammary cancer.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 85. 1954: 265
- Relation of thyroid to mammary gland structure in rat with special reference to male.Endocrinology. 1942; 31: 454-460
- The influence of the thyroid in malignant disease.Brit. J. Cancer. 1954; 8: 393-411
- Cancer death rates in Japan contrasted with those in England and Wales.Brit. J. Cancer. 1956; 10: 257
- Textbook of endocrinology. W. B. Saunders Company, Philadelphia1955 ed. 2.
Received: July 28, 1960
☆Presented at the Fifth Medical Assembly, University of Guadalajara, Guadalajara, Mexico, Nov. 10 to 14, 1959.
☆☆Aided in part by Thyroid-Cancer Research Grant from the Spokane County Cancer Association.
© 1961 Published by Elsevier Inc.