Research Article| Volume 52, ISSUE 4, P648-653, October 1962

Experimental treatment of coronary insufficiency by slight constriction of ascending aorta

      This paper is only available as a PDF. To read, Please Download here.


      Slight constriction of the ascending aorta, provoking a gradient of pressures no greater than 30 mm. Hg, augments coronary flow from 20 to 60 per cent, and this augmentation is not a consequence of increased cardiac work load. As long as the pressure gradient remains constant, the increase of coronary flow distributed through intercoronary anastomoses protects the heart from the effects of ligating one main branch of the left coronary artery and at the same time increases the capacity of most of the nonischemic cardiac muscle to maintain normal hemodynamics after a cardiac infarction. This method, therefore, could be effective in the treatment of coronary insufficiency.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Absolon K.B.
        • Aust J.B.
        • Varco R.L.
        • Lillehei C.W.
        Surgical treatment of occlusive coronary artery disease by endarterectomy or anastomotic replacement.
        Surg. Gynec. & Obst. 1956; 103: 180
        • Beck C.S.
        • Brofman B.L.
        Surgical management of coronary artery disease: Background, rationale, clinical experiences.
        Ann. Int. Med. 1956; 45: 975
        • Eckenhoff J.E.
        • Hafkenschiel J.H.
        • Harmel M.H.
        • Goodale W.T.
        • Lubin M.
        • Bing R.J.
        • Kety S.S.
        Measurement of coronary flow by the nitrous oxide method.
        Am. J. Physiol. 1958; 152: 356
        • Fuquay M.C.
        • Carey L.S.
        • Dahl E.V.
        Myocardial revascularization: A comparison of internal mammary and subclavian artery implantation in the laboratory.
        Surgery. 1958; 43: 226
        • Gaertner R.A.
        • Blalock A.
        Experimental coarctation of the ascending aorta.
        Surgery. 1956; 40: 712
        • Garamella J.J.
        • George V.P.
        • Anderson J.G.
        • Ditmanson M.L.
        • Hay L.S.
        Modified cardiopneumopexy employing pulmonary segmental resection. A mortality infarct study.
        Ann. Surg. 1957; 146: 864
        • Goodale W.T.
        • Lubin M.
        • Eckenhoff J.E.
        • Hafkenshiel J.H.
        • Banfield W.G.
        Coronary sinus catheterization for studying coronary blood flow and myocardial metabolism.
        Am. J. Physiol. 1948; 152: 340
        • Green H.D.
        • Gregg D.E.
        Changes in the coronary circulation following increased aortic pressure, augmented cardiac output, ischemia and valve lesions.
        Am. J. Physiol. 1940; 130: 126
        • Gregg D.E.
        Augmentation of left coronary inflow with elevation of left ventricular pressure and observations on the mechanism for increased coronary inflow with increased cardiac load.
        Am. J. Physiol. 1944; 142: 44
        • Gregg D.E.
        Coronary circulation in health and disease.
        in: Lea & Febiger, Philadelphia1950: 11-20 (chap. I)
        • Gregg D.E.
        • Green H.D.
        Effects of viscosity, ischemic, cardiac output and aortic pressure on coronary blood flow measured under a constant perfusion pressure.
        Am. J. Physiol. 1940; 130: 108
        • Gross H.
        • Blomberg A.E.
        • Rosenblatt M.
        • Kantrowitz A.
        • Schein C.J.
        • Ferreira R.
        Failure of cardiopericardiopexy to protect pigs against acute coronary occlusion.
        J. Thoracic Surg. 1957; 33: 769
        • Johnson R.J.
        • Wigger C.J.
        The alleged validity of coronary sinus flow as a criterion of coronary reactions.
        Am. J. Physiol. 1937; 118: 38
        • Litvak J.
        • Vineberg A.M.
        Left internal mammary arteriocardiopexy in therapy of coronary artery insufficiency. Preliminary experimental report.
        Surgery. 1957; 41: 738
        • Lord J.W.
        • Corillos E.
        • Lowenfels A.B.
        • Dysart R.
        • Neumann C.G.
        • Hinton J.W.
        Evaluation of operations for revascularization of the myocardium by the study of coronary blood flow using extracorporeal circulation.
        Surgery. 1958; 43: 202
        • Massino C.
        • Boffi L.
        Myocardial revascularization by new method of carrying blood directly into coronary circulation.
        J. Thoracic Surg. 1957; 34: 257
        • Thompson S.A.
        • Plachta A.
        Fourteen years' experience with cardiopexy in the treatment of coronary artery disease.
        J. Thoracic Surg. 1954; 27: 64
        • Vansant J.H.
        • Muller Jr., W.H.
        Experimental evaluation of internal mammary artery ligation as a method of myocardial revascularization.
        Surgery. 1959; 45: 840
        • Welch G.H.
        • Sarnoff S.J.
        • Braunwald E.
        • Stainsby W.N.
        • Case R.B.
        • Macruz R.
        The influence of cardiac output, aortic pressure and heart rate on myocardial oxygen utilization.
        in: S. Forum. 7. 1957: 294