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Research Article| Volume 52, ISSUE 4, P648-653, October 1962

Experimental treatment of coronary insufficiency by slight constriction of ascending aorta

DOI:https://doi.org/10.5555/uri:pii:0039606062900727
Experimental treatment of coronary insufficiency by slight constriction of ascending aorta
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      Abstract

      Slight constriction of the ascending aorta, provoking a gradient of pressures no greater than 30 mm. Hg, augments coronary flow from 20 to 60 per cent, and this augmentation is not a consequence of increased cardiac work load. As long as the pressure gradient remains constant, the increase of coronary flow distributed through intercoronary anastomoses protects the heart from the effects of ligating one main branch of the left coronary artery and at the same time increases the capacity of most of the nonischemic cardiac muscle to maintain normal hemodynamics after a cardiac infarction. This method, therefore, could be effective in the treatment of coronary insufficiency.
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      Article info

      Publication history

      Received: January 17, 1962

      Footnotes

      ☆Supported in part by Grant H-03137 from the United States Public Health Service and by the Houston Heart Association.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606062900727

      Copyright

      © 1962 Published by Elsevier Inc.

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