Research Article| Volume 52, ISSUE 3, P458-462, September 1962

Further study in experimental unilateral renal artery stenosis

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      The hypertension, which had previously been observed 3 months after the experimental production of unilateral renal arterial stenosis, has been shown to persist throughout a 6 month period of observation. In 2 hypertensive animals the kidneys were small and scarred, and renal blood flow was reduced. In the other 3 hypertensive dogs, the renal mass was moderately reduced, and renal blood flow per unit of kidney weight was normal. The distal renal artery pressures and pulse pressures were within the normal range.
      When the contralateral kidney was excised 5 to 7 days after production of renal artery stenosis, most of the animals died. The 12 surviving animals were hypertensive, and in 10 of them the test kidney was markedly hypertrophic 3 months later. In these animals, too, the distal renal artery pressure and pulse pressures were within the normal range. Renal blood flow was normal or slightly increased when calculated in cubic centimeters per gram of renal tissue.
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