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Abstract
The intravenous injection of Strep, salivarius into rats with arteriovenous fistulas has resulted in the production of endocarditis,
in 30 per cent of animals after 5 days. Three types of endocardial alteration similar
to those observed in the human were found: (a) those simulating rheumatic endocarditis
(b) those with the features of acute bacterial endocarditis, and (c) those of the
combined “rheumatic-like” lesions of the valve and foci of suppurative necrosis containing
bacterial masses.
Of great interest was the observation that animals with fistulas failed to clear bacteria
from their blood as readily as control animals. It is suggested that while cardiovascular
stress initiated by the fistula may be, as proposed by others, highly significant
in the production of such lesions, the persistence of small numbers of bacteria in
the blood stream may in part account for the apparent increased “susceptibility” of
cardiac endothelium to the development of such lesions in the presence of arteriovenous
communications.
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References
- The occurrence of endocarditis with valvular deformities in dogs with arteriovenous fistulas.Ann. Surg. 1950; 132: 577
- Role of cardiovascular stress in the pathogenesis of endocarditis and glomerulonephritis.A. M. A. Arch. Surg. 1951; 63: 421
Article info
Publication history
Received:
January 2,
1962
Identification
Copyright
© 1962 Published by Elsevier Inc.
