Research Article| Volume 52, ISSUE 3, P468-478, September 1962

Distensibility of isolated segments of normal aorta and of aortic grafts after implantation into dogs

      This paper is only available as a PDF. To read, Please Download here.


      Changes in volume in response to increasing intraluminal pressure of normal thoracic and abdominal aortas, fresh and frozen autografts, and homografts preserved either by freezing at −79 ° C. or freezing and drying in vacuo have been measured and used to calculate the volume, distensibility coefficients. Volume distensibility/pressure curves have been constructed by plotting the distensibility coefficients against the intraluminal pressure.
      The volume distensibility/pressure curves of aortic autografts at 4, 11, and 33 weeks after implantation were similar in shape to that of normal aorta, but the distensibility coefficients were consistently lower. This general resemblance was taken to mean that both the elastic tissue and the collagen in the wall of the autograft took part in the response to distention, though the activity of the former appeared to be slightly impaired.
      The volume distensibility/pressure curves of all the homografts showed the very flat curve characteristic of collagenous tissue alone. The distensibility coefficients were much lower at low pressures than normal aorta or aortic autografts, and approximately the same at higher pressures. It appeared that the elastic tissue in the wall of the homograft, though prominent histologically, played very little part in the response to distention 4 weeks after transplantation.
      One Teflon prosthesis, implanted 3 months, gave a volume distensibility/pressure curve which corresponded to Hooke's law for inorganic materials.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Bramwell J.C.
        • Hill A.V.
        The velocity of pulse wave in man.
        in: ed. 2. Proc. Roy. Soc. 93. 1922: 298
        • Burton A.C.
        Relation of structure to function of the tissues of the wall of blood vessels.
        Physiol. Rev. 1954; 34: 619
        • Hallock P.
        • Benson I.C.
        Studies on the elastic properties of isolated human aorta.
        J. Clin. Invest. 1937; 16: 595
        • Ham A.W.
        in: ed. 2. J. B. Lippincott Company, Philadelphia and London1953: 410
        • Hass G.
        Description of a method of isolating elastic tissue.
        Arch. Path. 1942; 34: 807
        • Macpherson A.I.S.
        • Duthie R.B.
        The healing of vascular grafts.
        J. Roy. Coll. Surgeons, Edinburgh. 1957; 3: 98
        • Newton W.T.
        • Stokes J.M.
        • Burton A.R.
        Changes in the elasticity of arterial substitutes following implantation.
        Surgery. 1959; 46: 579
        • Remington J.W.
        Hysteresis loop behavior of the aorta and other tissues.
        Am. J. Physiol. 1955; 180: 83
        • Roach M.R.
        • Burton A.R.
        The reason for the shape of the distensibility curves of arteries.
        Canad. J. Biochem. 1957; 35: 681
        • Roy C.S.
        The elastic properties of the arterial wall.
        J. Physiol. 1881; 3: 125