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Abstract
Changes in volume in response to increasing intraluminal pressure of normal thoracic
and abdominal aortas, fresh and frozen autografts, and homografts preserved either
by freezing at −79 ° C. or freezing and drying in vacuo have been measured and used
to calculate the volume, distensibility coefficients. Volume distensibility/pressure
curves have been constructed by plotting the distensibility coefficients against the
intraluminal pressure.
The volume distensibility/pressure curves of aortic autografts at 4, 11, and 33 weeks
after implantation were similar in shape to that of normal aorta, but the distensibility
coefficients were consistently lower. This general resemblance was taken to mean that
both the elastic tissue and the collagen in the wall of the autograft took part in
the response to distention, though the activity of the former appeared to be slightly
impaired.
The volume distensibility/pressure curves of all the homografts showed the very flat
curve characteristic of collagenous tissue alone. The distensibility coefficients
were much lower at low pressures than normal aorta or aortic autografts, and approximately
the same at higher pressures. It appeared that the elastic tissue in the wall of the
homograft, though prominent histologically, played very little part in the response
to distention 4 weeks after transplantation.
One Teflon prosthesis, implanted 3 months, gave a volume distensibility/pressure curve
which corresponded to Hooke's law for inorganic materials.
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Article info
Publication history
Received:
November 13,
1961
Footnotes
☆Supported by a grant from the Scottish Hospitals Endowment Research Trust.
Identification
Copyright
© 1962 Published by Elsevier Inc.
