Advertisement
Research Article| Volume 51, ISSUE 2, P224-232, February 1962

Prediction of blood volume in normal human adults

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The circulating blood volumes in 155 normal adult men and women were determined by the I131 HSA method. The measured volumes were plotted against body weight, surface area, and the height cubed-body mass formulas. Significant statistical improvement was attained when the data were plotted against predicted volumes based upon computer-corrected surface area and height cubed-body mass formulas. Both computer-corrected formulas yield the same prediction data when sex, height, and weight are the only parameters used. The usefulness of the prediction formulas was demonstrated when data obtained by other workers using different methods of estimating blood volume showed as good correlation with prediction as did our data.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Allen T.H.
        • Peng M.T.
        • Chen K.P.
        • Huang T.F.
        • Chang C.
        • Fang H.S.
        Prediction of blood volume and adiposity in man from body weight and cube of height.
        Metabolism. 1956; 5: 328
        • Baker R.J.
        • Kozoll D.D.
        • Meyer K.A.
        The Use of surface area as a basis for establishing normal blood volume.
        Surg. Gynec. & Obst. 1957; 104: 183
        • Behnke A.R.
        Physiologic studies pertaining to deep sea diving and aviation, especially in relation to the fat content and composition of the body.
        Harvey Lect. 1941–1942; 37: 198
        • Behnke A.R.
        The relation of lean body weight to metabolism and some consequent systemizations. I. Development of formulas for the prediction of lean body weight from basal metabolism.
        Ann. N. Y. Acad. Sc. 1953; 56: 1095
        • Berson S.A.
        • Yalow R.S.
        The use of K42 or P32 labeled erythrocytes and I131 tagged human serum albumin in simultaneous blood volume determinations.
        J. Clin. Invest. 1952; 31: 572
      1. Cates, C. E., Green, T. H., Seaber, R. Y., and Stewart, R. A.: RAP—a regression analysis program, Shell Oil Co., Houston, Texas.

        • Chaplin Jr., H.
        • Mollison P.L.
        Correction for plasma trapped in the red cell column of the hematocrit.
        Blood. 1952; 7: 1227
        • Chaplin Jr., H.
        • Mollison P.L.
        • Vetter H.
        The body/venous hematocrit ratio: its constancy over a wide hematocrit range.
        J. Clin. Invest. 1953; 32: 1309
        • Clark J.H.
        • Nelson W.
        • Lyons C.
        • Mayerson H.S.
        • Decamp
        Chronic shock: the problem of reduced blood volume in the chronically ill patient.
        Ann. Surg. 1947; 125: 618
        • Gibson J.G.
        • Evans Jr., W.A.
        Clinical studies of the blood volume. II. The relation of total blood volume to venous pressure, blood velocity rate, physical measurements, age, and sex in 90 normal humans.
        J. Clin. Invest. 1937; 16: 317
        • Gibson J.G.
        • Peacock W.C.
        • Seligman A.M.
        • Sack T.
        The circulating blood volume measured simultaneously by the radioactive iron and dye methods.
        J. Clin. Invest. 1946; 25: 838
        • Gray S.J.
        • Frank H.
        The simultaneous determination of red cell mass and plasma volume in man with radioactive sodium chromate and chromic chloride.
        J. Clin. Invest. 1953; 32: 1000
        • Gregersen M.I.
        • Rawson R.A.
        Blood volume.
        Physiol. Rev. 1959; 39: 307
        • Gurney C.W.
        • Bolt R.J.
        The simultaneous use of chromium labeled erythrocytes and I131 tagged human serum albumin in blood volume determinations.
        Univ. Michigan M. Bull. 1956; 22: 319
      2. Hidalgo, J. U., Nadler Samuel, B., and Bloch, T.: A computer approach to the mathematical correlation of biological data. In press.

        • Hlad C.J.
        • Tanz R.
        An analysis of technical errors in radioalbumin blood volume methods and presentation of a modified method.
        J. Lab. & Clin. Med. 1958; 52: 289
        • Hope A.
        • Veret D.
        Further observations on the distribution of red cells and plasma in disease—the low body hematocrit: venous hematocrit ratio.
        Clin. Sc. 1955; 14: 501
        • Nachman H.M.
        • James G.W.
        • Moore J.W.
        • Evans E.L.
        A comparative study of red cell volumes in human subjects with radioactive phosphorus tagged red cells and T-1824.
        J. Clin. Invest. 1950; 29: 258
      3. Nadler, S. B., Hidalgo, J. U., and Bloch, T.: Unpublished data.

        • Reilly W.A.
        • Helwig H.I.
        • Scott K.G.
        Blood volume measurements in cancer using the Cr51 red-blood cell tagging method.
        Cancer. 1956; 9: 273
        • Seed L.
        • Kaplan E.
        • Eggan K.G.
        Blood volume studies with the use of I131 tagged albumin.
        Ann. Surg. 1955; 21: 533
        • Senn L.Y.
        • Karlson K.E.
        Methodology and actual error of plasma volume determination.
        Surgery. 1958; 44: 1095
        • Twigg H.
        • Nakayama L.
        • Goodwin M.A.
        Blood volume studies in humans using radioiodinated human serum albumin.
        Maryland M. J. 1958; 7: 150
        • Vazquez O.N.
        • Newerly K.
        • Yalow R.S.
        • Berson S.A.
        Determination of trapped plasma in the centrifuged erythrocyte volume of normal human blood with radioiodinated (I131) human serum albumin and radiosodium (Na24).
        J. Lab. & Clin. Med. 1952; 39: 595
        • Wennesland R.
        • Brown E.
        • Hopper Jr., J.
        • Hodges J.L.
        • Guttentag O.E.
        • Scott K.G.
        • Tucker I.N.
        • Bradley B.
        Red cell, plasma and blood volume in healthy men measured by radiochromium (Cr51) cell tagging and hematocrit: influence of age, somatotype and habits of physical activity on the variance after regression of volumes to height and weight combined.
        J. Clin. Invest. 1959; 38: 1065