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In vitro selection of chemotherapeutic agents for perfusion therapy of human cancer

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      Abstract

      A method to aid in the selection of agents to be used for perfusion chemotherapy of human cancers is presented. The test establishes the sensitivity of the patient's tumor to chemotherapeutic agents in vitro. Explants of the tumor, growing in tissue culture, are exposed to several drugs and the cytotoxic effect of each is established. One of the drugs tested is then used in the perfusion treatment of that patient's tumor.
      Of 48 isolation-perfusion operations performed, a comparison of the clinical effects with the tissue culture results was possible in 16. There was a positive correlation between the in vivo and in vitro results in 13 of the 16 cases.
      The results of this initial study suggest that this tissue culture sensitivity test may be a useful tool in the selection of drugs for perfusion.
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