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Abstract
A method to aid in the selection of agents to be used for perfusion chemotherapy of
human cancers is presented. The test establishes the sensitivity of the patient's
tumor to chemotherapeutic agents in vitro. Explants of the tumor, growing in tissue
culture, are exposed to several drugs and the cytotoxic effect of each is established.
One of the drugs tested is then used in the perfusion treatment of that patient's
tumor.
Of 48 isolation-perfusion operations performed, a comparison of the clinical effects
with the tissue culture results was possible in 16. There was a positive correlation
between the in vivo and in vitro results in 13 of the 16 cases.
The results of this initial study suggest that this tissue culture sensitivity test
may be a useful tool in the selection of drugs for perfusion.
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Article info
Publication history
Received:
July 26,
1961
Footnotes
☆The investigation on which this paper was based was supported in part by grants from the National Cancer Institute, United States Public Health Service, Bethesda, Md., and the Shrine Tuberculosis and Cancer Foundation.
Identification
Copyright
© 1962 Published by Elsevier Inc.
