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Abstract
Myocardial metabolism was studied before, during, and following a 30 minute period
of hypothermic cardiac arrest produced by total body cooling during cardio-pulmonary
bypass.
Deep hypothermia results in a decreased myocardial utilization of oxygen glucose,
lactate, pyruvate, total fatty acids (TFA), and unesterified fatty acids. Following
restoration of normal circulation at normal temperatures, most of these values return
to normal but the myocardial uptake of oxygen and TFA remains depressed. The addition
of total circulatory arrest during deep hypothermia results in continued depression
of glucose utilization but no other measurements were found to be affected.
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References
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Article info
Footnotes
☆These studies were supported by the National Heart Institute, Grant No. H-3791, Massachusetts Heart Association, Grant No. 334, and the “200 Club” of the New England Center Hospital.
☆☆Read at the Twenty-third Annual Meeting of the Society of University Surgeons, Cleveland, Ohio, Feb. 8–10, 1962.
Identification
Copyright
© 1962 Published by Elsevier Inc.
