Society of University Surgeons| Volume 52, ISSUE 1, P47-54, July 1962

The effects of coronary artery perfusion on myocardial metabolism during hypothermic cardiac arrest

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      Myocardial metabolism was studied before, during, and following a 30 minute period of hypothermic cardiac arrest produced by total body cooling during cardio-pulmonary bypass.
      Deep hypothermia results in a decreased myocardial utilization of oxygen glucose, lactate, pyruvate, total fatty acids (TFA), and unesterified fatty acids. Following restoration of normal circulation at normal temperatures, most of these values return to normal but the myocardial uptake of oxygen and TFA remains depressed. The addition of total circulatory arrest during deep hypothermia results in continued depression of glucose utilization but no other measurements were found to be affected.
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