Society of University Surgeons| Volume 52, ISSUE 1, P117-126, July 1962

Oral cation exchange resin therapy for ammonia intoxication in dogs

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      • 1.
        1. Oral cation exchange resin (Kayexalate) and sorbitol therapy have been shown to be effective in preventing a rise in systemic venous blood ammonia in dogs with Eck fistulas given blood by gastric tube.
      • 2.
        2. Control studies using neomycin and magnesium citrate by tube were unsuccessful in preventing this rise in blood ammonia.
      • 3.
        3. Orally administered Kayexalate and sorbitol are effective in significantly lowering blood ammonia levels in Eck-fistula dogs given an intravenous infusion of ammonium citrate, 2.0 per cent.
      • 4.
        4. Clinical therapeutic experience with the oral cation exchange resin—sorbitol regimen was proposed.
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