Society of University Surgeons| Volume 52, ISSUE 1, P195-202, July 1962

The role of histamine release in chronic cystic mastitis

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      Data are presented showing an increase in histamine content of the breast afflicted with chronic cystic mastitis as compared to normal.
      Breast cyst fluid contains almost as much of the amine as human blood.
      β-estradiol and progesterone have been found capable of histamine release from breast at catalytic concentrations.
      We suggest that those cyclic changes in the breast presenting as increase in size and turgor are to a considerable extent the result of water imbibition due to the permeability effects of histamine action.
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